(-)-Eseroline fumarate  (Synonyms: Eseroline fumarate)

(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum^[1][2].

(-)-Eseroline fumarate (0.5 mM; 0-25 hr) 时间依赖性地诱导小鼠神经母细胞瘤 N1E-115、大鼠胶质瘤 C6 和神经母细胞癌-胶质瘤杂交 NG 108-15 中的 LDH 泄露^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Eseroline fumarate (盐酸; 10 mg/kg; 静脉注射; 单剂量) 诱导成年杂种猫的大脑皮层释放5-HT^[2]。
(-)-Eseroline fumarate (水杨酸; 9 mg/kg; 皮下注射; 单剂量) 在小鼠甩尾试验中显示出镇痛的作用，并强烈地降低 Physostigmine (HY-N6608) 的抗伤害作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

334.37

C₁₇H₂₂N₂O₅

70310-73-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Somani SM, et al. Eseroline, a metabolite of physostigmine, induces neuronal cell death. Toxicol Appl Pharmacol. 1990 Oct;106(1):28-37.  [Content Brief]

  [2]. Bartolini A, et al. Eseroline: a new antinociceptive agent derived from physostigmine with opiate receptor agonist properties. Experimental in vivo and in vitro studies on cats and rodents. Neurosci Lett. 1981 Sep 1;25(2):179-83.  [Content Brief]

  [3]. Harris LS, et al. Narcotic-antagonist analgesics: interactions with cholinergic systems. J Pharmacol Exp Ther. 1969 Sep;169(1):17-22.  [Content Brief]