Miravirsen  (Synonyms: SPC-3649)

Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection^[1][2].

miR-122^[1]

Miravirsen 被认为主要通过与成熟的 miR-122 杂交并阻断其与 HCV RNA 的相互作用来发挥作用，其靶序列也存在于 pri- 和 pre-miR-122^[1]。
Miravirsen 以纳摩尔亲和力结合 pri- 和 pre-miR-122 的茎环结构，并抑制 Dicer 和 Drosha 介导的 miR-122 前体加工^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Miravirsen (SPC-3649；2.5-25 mg/kg；静脉注射；每日一次，持续 3 天) 抑制小鼠的 miR-122 活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4967.00

1072874-90-8

固体

Off-white to light yellow

RNA, (P-thio)((2'-O,4'-C-methylene)m5C-dC-(2'-O,4'-C-methylene)A-dT-dT-(2'-O,4'-C-methylene)G-(2'-O,4'-C-methylene)m5U-dC-dA-(2'-O,4'-C-methylene)m5C-dA-(2'-O,4'-C-methylene)m5C-dT-(2'-O,4'-C-methylene)m5C-(2'-O,4'-C-methylene)m5C)

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. Luca F R Gebert, et al. Miravirsen (SPC3649) can inhibit the biogenesis of miR-122. Nucleic Acids Res. 2014 Jan;42(1):609-21.  [Content Brief]

  [2]. Elmén J, et, al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 2008 Mar;36(4):1153-62.  [Content Brief]