2. GPCR/G Protein
  3. Platelet-activating Factor Receptor (PAFR)
  4. MK 287

MK 287 是一种强效、选择性且具有口服活性的血小板活化因子受体 (PAFR) 拮抗剂。MK 287 能够抑制 [3H] C18-PAF 与人血小板、多形核白细胞 (PMN) 和肺细胞膜的结合，其 K1 值分别为 6.1、3.2 和 5.49 nM。MK 287 可以抑制 PAF 诱导的血浆中血小板或凝胶过滤血小板的聚集，以及 PMN 释放弹性蛋白酶，其 ED50 值分别为 56、1.5 和 4.4 nM。MK 287 可用于心血管疾病的研究，如血栓形成。

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MK 287

MK 287 Chemical Structure

CAS No. : 135947-75-0

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MK 287 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis[1].

分子量

510.60

Formula

C25H34O9S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MK 287 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK 287135947-75-0MK287MK-287Platelet-activating Factor Receptor (PAFR)platelet-activating factor receptorPAFRpolymorphonuclear leukocyteplatelets aggregationelastasePMNsthrombosisInhibitorinhibitorinhibit

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目录号：
HY-106899
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