1. Cytoskeleton
  2. Myosin
  3. ML-9 Free Base

ML-9 Free Base 

目录号: HY-100932A
产品使用指南

ML-9 (Free Base) 是 Akt 激酶的选择性强效抑制剂,可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子 1 (STIM1) 的活性。 ML-9 (Free Base) 抑制 MLCK,PKA 和 PKC 活性,Ki 值分别为 4、32 和 54 μM。 ML-9 通过刺激自噬小体的形成并抑制其降解来诱导自噬 (autophagy)。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ML-9 Free Base Chemical Structure

ML-9 Free Base Chemical Structure

CAS No. : 110448-31-2

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

ML-9 Free Base 的其他形式现货产品:

Customer Review

Other Forms of ML-9 Free Base:

注册 MCE会员完成审核
即刻享有 哈根达斯、星巴克、KFC、百果园 等专属礼券

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].

体外研究
(In Vitro)

ML9 (Free Base) (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death[2].
ML9 (Free Base) (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Neonatal rat ventricular myocytes (NRVM) cells
Concentration: 0, 10, 50 and 100 μM
Incubation Time: 0, 1, 4, 8 and 24 hours
Result: Decreased cell viability at 50–100 μM concentration.

Apoptosis Analysis[1]

Cell Line: Neonatal rat ventricular myocytes (NRVM) cells
Concentration: 50 μM
Incubation Time: 0, 1, 4, 8 hours
Result: Induced cardiomyocyte death through necrosis and apoptosis.
分子量

324.83

Formula

C₁₅H₁₇ClN₂O₂S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
ML-9 Free Base
目录号:
HY-100932A
需求量: