2. MAPK/ERK Pathway
  3. MNK
  4. MNK1/2-IN-8

MNK1/2-IN-8 (compound 15b) 是一种 MNK1/2 抑制剂，对 Mnk1 和 Mnk2 的 IC50 值分别为 0.8 和 1.5 nM。MNK1/2-IN-8 表现出抗增殖活性并诱导细胞周期阻滞。

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MNK1/2-IN-8

MNK1/2-IN-8 Chemical Structure

CAS No. : 2430793-35-2

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MNK1/2-IN-8 相关抗体

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查看 MNK 亚型特异性产品:

查看所有亚型
MNK1 MNK2 MNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest[1].

IC50 & Target

MNK1

0.8 nM (IC50)

MNK2

1.5 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 GI50
1.73 μM
Compound: 15b
Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay
[PMID: 38759457]
HL-60 GI50
2.39 μM
Compound: 15b
Antiproliferative activity against human HL-60 cells incubated for 72 hrs by trypan blue staining based analysis
Antiproliferative activity against human HL-60 cells incubated for 72 hrs by trypan blue staining based analysis
[PMID: 38759457]
K562 GI50
3.6 μM
Compound: 15b
Antiproliferative activity against human K562 cells incubated for 72 hrs by trypan blue staining based analysis
Antiproliferative activity against human K562 cells incubated for 72 hrs by trypan blue staining based analysis
[PMID: 38759457]
L02 GI50
11.58 μM
Compound: 15b
Antiproliferative activity against human L02 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human L02 cells incubated for 96 hrs by MTT assay
[PMID: 38759457]
MOLM-13 GI50
1.59 μM
Compound: 15b
Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by trypan blue staining based analysis
Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by trypan blue staining based analysis
[PMID: 38759457]
体外研究
(In Vitro)

MNK1/2-IN-8 (compound 15b) 对 HCT-116、MOLM-13、K562 和 HL-60 的 GI50 值分别为 7.68、1.59、3.60 和 2.39 μM [1]。
MNK1/2-IN-8 (compound 15b) (1、2和4μM, 24 h) 诱导 MOLM-13 和 K562 细胞系细胞发生周期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MNK1/2-IN-8 相关抗体:
体内研究
(In Vivo)

MNK1/2-IN-8 (compound 15b) 在小鼠肺癌 LL/2 细胞异种移植模型中抑制肿瘤生长[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

436.51

Formula

C26H24N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MNK1/2-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNK1/2-IN-82430793-35-2MNKMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseMOLM-13K562cell cycleLL/2 syngeneic modelHCT-116HL-60Inhibitorinhibitorinhibit

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