1. Immunology/Inflammation
  2. STING
  3. MSA-2

MSA-2 

目录号: HY-136927
产品使用指南

MSA-2 是一种口服非核苷酸 STING 激动剂,对人的 STING 亚型 WT 和 HAQ 的 EC50 分别为 8.3 和 24 μM。MSA-2 在同基因小鼠肿瘤模型中显示抗肿瘤活性,刺激肿瘤分泌干扰素-β,诱导肿瘤消退,具有持久的抗肿瘤免疫,并与抗 PD-1 协同作用。

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MSA-2 Chemical Structure

MSA-2 Chemical Structure

CAS No. : 129425-81-6

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Description

MSA-2 is an orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1].

In Vivo

MSA-2 dosed via either PO or SC regimens achieved comparable exposure in both tumor and plasma. MSA-2 also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes, and dosing regimens were identified that induced complete tumor regressions in 80 to 100% of treated animals[1].
MSA-2 (PO: 60 mg/kg or SC: 50 mg/kg; single dose) that effectively inhibits tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor[1].

Animal Model: MC38 tumor-bearing C57BL6 mice[1]
Dosage: 60 mg/kg
Administration: P.o. ; s.c (50 mg/kg); single dose
Result: PO or SC doses of MSA-2 that effectively inhibited tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor.
Molecular Weight

294.32

Formula

C₁₄H₁₄O₅S

CAS No.

129425-81-6

SMILES

O=C(C1=CC(C(S1)=C2)=CC(OC)=C2OC)CCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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× = ×
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Keywords:

MSA-2MSA2MSA 2STINGStimulator of Interferon GenesTMEM173MITAERISMPYSinterferon-βsecretionimmunityMC38tumorTNF-αInhibitorinhibitorinhibit

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产品名称:
MSA-2
目录号:
HY-136927
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