2. Immunology/Inflammation
  3. Interleukin Related
  4. MT204

MT204 是一种靶向人类和恒河猴来源 IL-2 的人源化 IgG1 抗体抑制剂。MT204 可阻止可溶性 IL-2 与中等亲和力 IL-2 受体结合，并阻断 CD25 结合的 IL-2 与高亲和力 IL-2 受体结合。MT204 在恒河猴异基因皮肤移植模型中具有良好的耐受性和强效的免疫抑制活性。MT204 具有线性药代动力学、合理的血清半衰期、良好的安全性和疗效迹象，有望用于免疫治疗。

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MT204 Chemical Structure

MT204 Chemical Structure

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Customer Review

MT204 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MT204 is a humanized IgG1 antibody inhibitor targeting IL-2 of human and rhesus monkey origin. MT204 prevents soluble IL-2 from binding to intermediate-affinity IL-2 receptors and blocks CD25-bound IL-2 on high-affinity IL-2 receptors. MT204 has potently anti-proliferative activity with NKL cells and primary NK cells. MT204 has good tolerability and potent immunosuppressive activity in allogeneic skin graft model of rhesus monkey, promising for immunosuppressive and anti-proliferative therapy[1].

IC50 & Target

IL-2

0.58 nM (Kd)

体外研究
(In Vitro)

MT204 (1-100 μg/mL，4 天) 剂量依赖性地抑制 mitogen concavalin A 刺激的恒河猴 PBMCs 的增殖和 IFN-γ 分泌[1]。
MT204 可以阻断高亲和力 IL-2 受体上 CD25 结合的 IL-2，其 kd 为 0.58 nM[1][2]。
MT204 (5 小时) 剂量依赖性地降低 CTLL-2 细胞中 IL-2 诱导的 IL-4 受体 α 亚基 (CD124) 的细胞表面表达[2]。
MT204 (5 天) 抑制 IL-2 诱导的 NKL 细胞和 T 细胞增殖，其 IC50 s 分别约为 1.3 nM and 0.21 nM[2]。
MT204 (15 分钟) 在亚纳摩尔浓度下强效拮抗 IL-2 的下游信号传导，显著降低原代人类淋巴细胞中 IL-2 刺激后的 pY-STAT3 水平[2]。
MT204 显著抑制 IL-2 诱导 NKL 细胞、T 细胞和所有 NK 细胞增殖，与 CD25 表达水平无关，其 IC50 s 分别为 0.35-0.36 nM, 0.33 nM, and 0.1-0.13 nM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MT204 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Indicator value
Rhesus monkey 2, 10, 50 or repeat 50 mg/kg i.v. Cmax 1 mg/mL
Rhesus monkey 2, 10, 50 or repeat 50 mg/kg i.v. T1/2 326.4 hr
体内研究
(In Vivo)

MT204 (50 mg/kg，静脉注射，第 0 天、第 5 天和第 12 天，以 1.5 mL/kg/h 的速度，1 小时内给药) 在恒河猴同种异体皮肤移植模型中可显著延迟同种异体皮肤移植的排斥反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MHC-matched rhesus monkeys (Naive, captive bred, 3.8-9.6 k) were grafted on the inter-scapular area with circular MHC-mismatched rhesus skin (2 cm, lower abdomen)[1].
Dosage: 50 mg/kg
Administration: i.v., day 0, day 5 and day 12 at a speed of 1.5 ml/kg/h over 1 h, and then collected grafts and blood samples1.
Result: Extended graft survival to days 11, 13 and 14 (median day 13) compared vehicle-treatment (complete skin rejection on day 9.5).
Notably delayed necrosis of allogeneic grafts while the vehicle treated grafts showed complete necrosis since day 9.
Alleviated inflammation and inhibited multifocal epithelial hyperplasia with focal para-keratosis, and intra-epidermal infiltrates on epidermis. Potently antagonizes IL-2 in both CD25+ and CD25- cells.
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MT204 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT204MT 204MT-204Interleukin RelatedILInterleukin-2 (IL-2)ImmunotherapyMonoclonal antibodyPrimateTransplantationInhibitorinhibitorinhibit

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目录号：
HY-P991270
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