1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GABA Receptor
  3. Muscimol hydrochloride

Muscimol hydrochloride  (Synonyms: Agarin hydrochloride; Agarine hydrochloride)

目录号: HY-N2313B 纯度: ≥95.0%
COA 产品使用指南

Muscimol (Agarin; Agarine) hydrochloride 是一种具有精神活性的异恶唑。Muscimol hydrochloride 也是抑制性神经递质 GABA 离子型受体的选择性激动剂。Muscimol hydrochloride 可以从毒蝇伞和相关蘑菇中分离出来。总之,Muscimol 是一种有效的 GABAA 受体激动剂 (EC50=0.2 μM),部分 GABAC 受体 激动剂和无活性的 GABAB 受体 激动剂。Muscimol hydrochloride 具有镇静、抗焦虑和致幻作用。

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Muscimol hydrochloride Chemical Structure

Muscimol hydrochloride Chemical Structure

CAS No. : 3579-03-1

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Muscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a selective agonist of the inhibitory neurotransmitter, GABA ionotropic receptors. Muscimol hydrochloride can be isolated from from Amanita muscaria and related mushrooms. All in all, Muscimol is a potent GABAA receptors agonist (EC50=0.2 μM), a partial GABACreceptors agonist, and an inactive GABAB receptors agonist. Muscimol hydrochloride has calming, anti-anxiety and hallucinatory effects[1].

IC50 & Target

EC50: 0.2 μM (GABACreceptors)[1]

体内研究
(In Vivo)

Muscimol 影响前额叶皮层的功能,并且在注射到腹侧前额叶皮层后(1μL,5μg/μL;前额叶皮层输注),损害猴子在计数任务中的表现,但在注射到背侧前额叶皮层后没有影响[2]
Muscimol 影响前扣带皮层 (ACC) 的微量调节,并且在 10 秒微量组中(62.5 或 125 µg/侧)对抑制噪声刺激没有影响[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rhesus monkeys (Macaca mulatta) (5 kg and 5.5 kg)[2]
Dosage: 1 μL, 5 μg/μL
Administration: Implanted drug delivery tubes and infusion; single dose
Result: Increased the error types and reaction time during the counting task.
分子量

150.56

Formula

C4H7ClN2O2

CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥95.0%

参考文献
  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Muscimol hydrochloride
目录号:
HY-N2313B
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