2. Anti-infection
  3. Bacterial
  4. Neamine

Neamine ，一种新霉素的降解产物，是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌，抗肿瘤和神经保护活性。

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Neamine Chemical Structure

Neamine Chemical Structure

CAS No. : 3947-65-7

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规格 价格 是否有货 数量
1 mg ￥980
In-stock
5 mg ￥2750
In-stock
10 mg ￥4400
In-stock
25 mg
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Other Forms of Neamine:

Neamine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities[1][2].

体外研究
(In Vitro)

Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM[1].
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neamine 相关抗体:

Cell Proliferation Assay[1]

Cell Line: AsPC-1 cells
Concentration: 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM
Incubation Time: 48 hours
Result: Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.
体内研究
(In Vivo)

Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells[1]
Dosage: 30 mg/kg, 60 mg/kg
Administration: Subcutaneous injection; daily; for 14 days
Result: Had anti-tumor effects on AsPC-1 xenograft models.
分子量

322.36

Formula

C12H26N4O6
CAS 号
中文名称

新霉胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neamine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neamine3947-65-7新霉胺BacterialAngiogeninaminoglycosideantibioticantibacterialantitumorNeomycinKi-67CD31anti-angiogenesisneuroprotectiveInhibitorinhibitorinhibit

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目录号：
HY-N7449
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