Neuropeptide W-23 (human) (TFA)  (Synonyms: NPW-23 TFA)

Neuropeptide W-23 (human) (NPW-23) TFA, the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8)^[1].

NPBW1, NPBW2^[1]

Neuropeptide W-23 (human) (NPW-23) increases the I_Ca,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7^[1].
Neuropeptide W-23 (human) increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats^[2].
Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2698.03

C₁₁₉H₁₈₃N₃₅O₂₈S.C₂HF₃O₂

Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-LeuMet-Gly-Leu

WYKHVASPRYHTVGRAAGLLMGL

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ji L, et al. Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. J Hypertens. 2015 Dec;33(12):2431-42.  [Content Brief]

  [2]. Pate AT, et al. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R804-10.  [Content Brief]

  [3]. Naso T, et al. Central neuropeptide W has anorexigenic effect in rats. J Anim Physiol Anim Nutr (Berl). 2014 Apr;98(2):228-34.  [Content Brief]