2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. NGD94-1

NGD94-1 是一种强效且选择性的多巴胺 D4 受体 (dopamine D4 receptor) 拮抗剂。NGD94-1 对克隆人源 D4.2 受体 (human D4.2 receptor) 具有高亲和力 (Ki = 3.6 nM)。NGD94-1 在 Phencyclidine (PCP) 诱导的猴子模型中可调节前额叶-纹状体系统的认知功能，并调控多巴胺能神经传递。NGD94-1 可用于神经系统疾病的相关研究[1][2]。

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NGD94-1

NGD94-1 Chemical Structure

CAS No. : 178928-68-2

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规格 价格 是否有货
1 mg ￥595
询问价格 & 货期
5 mg ￥1400
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10 mg ￥2100
询问价格 & 货期
25 mg ￥4130
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50 mg 询价 询问价格 & 货期
100 mg 询价 询问价格 & 货期

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Customer Review

Other Forms of NGD94-1:

NGD94-1 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NGD94-1 is a potent and selective dopamine D4 receptor antagonist. NGD94-1 shows high affinity for the cloned human D4.2 receptor (Ki = 3.6 nM). NGD94-1 modulates the cognitive functions of the frontostriatal system and regulates dopaminergic transmission in Phencyclidine (PCP)-induced monkeys. NGD94-1 can be used for neurological disease research[1][2].

IC50 & Target[2]

hD4.2 Receptor

3.6 nM (Ki)

体外研究
(In Vitro)

NGD 94-1 对 D4.2 受体的选择性比其他许多靶点高 600 倍以上，然而，其对 5-HT1A 受体 (选择性低约 50 倍) 和 5-HT3 受体 (选择性低约 200 倍) 的选择性则显著较低[2]。
NGD 94-1在 HEK293/D4 细胞中可诱导 cAMP 积累的抑制，但在未转染的 HEK293 细胞中不影响 Forskolin (HY-15371) 刺激的 cAMP 生成，表明其抑制作用是通过转染的多巴胺 D4 受体特异性介导[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NGD94-1 相关抗体:
体内研究
(In Vivo)

NGD94-1 (1-5 mg/kg，肌肉注射，测试前 45 分钟给药) 可逆转 PCP 预处理猴子的认知缺陷，并增加脑池脑脊液中 HVA 的积累[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Young-adult vervet (Cercopithecus aethiops sabaeus) monkeys[1]
Dosage: 1 and 5 mg/kg
Administration: i.m., 45 min prior to testing
Result: Significantly reversed the impaired successful performance of PCP-treated subjects (from 58% to 79% accuracy) at 1 mg/kg.
Ameliorated the PCP-induced impairments (from 73% to 86% accuracy) at 5 mg/kg.
Reduced barrier reaching and perseverative responding at both doses in PCP-treated monkeys.
Unaffected response initiation latencies and motor problems in PCP-treated monkeys.
Unaffected accurate performance at 1 mg/kg in saline pretreated monkeys.
Slightly impaired successful performance at 5 mg/kg in saline pretreated monkeys.
Failed to affect response initiation latencies or motor problems at both doses in saline pretreated monkeys.
Failed to affect HVA levels relative to saline in control subjects.
Significantly increased HVA concentrations in the CSF in PCP-treated subjects.
分子量

320.39

Formula

C18H20N6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

NGD94-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NGD94-1178928-68-2Dopamine Receptordopamine D4 receptorhuman D4.2 receptorfrontostriatalPhencyclidinevervet monkeyInhibitorinhibitorinhibit

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目录号：
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