2. Cell Cycle/DNA Damage
  3. Antifolate
  4. Nolatrexed

Nolatrexed  (Synonyms: AG 337 free base)

目录号: HY-13714
产品使用指南 技术支持

Nolatrexed (AG 337 free base) 是一种具有抗叶酸活性的化合物，口服生物利用度高，在抑制剂量下主要毒性为胃肠道反应，可安全地以特定剂量口服用于抑制，对血小板和中性粒细胞有影响。

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Nolatrexed

Nolatrexed Chemical Structure

CAS No. : 147149-76-6

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规格 价格 是否有货 数量
1 mg ￥552
1 - 2 周
5 mg ￥1789
1 - 2 周
10 mg ￥3212
1 - 2 周
25 mg ￥5346
1 - 2 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Nolatrexed:

Nolatrexed 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
0.8 μM
Compound: 3
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
[PMID: 9873719]
CCRF-CEM IC50
0.81 μM
Compound: 21
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
GC3/MTK- IC50
1 μM
Compound: 21
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
[PMID: 8459400]
HT-29 IC50
3.7 μM
Compound: 3
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
[PMID: 9873719]
L1210 IC50
1 μM
Compound: 21
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
L1210 IC50
1.1 μM
Compound: 3
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
[PMID: 9873719]
LY3.7.2C TK-/- cell line IC50
1.5 μM
Compound: 3
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
[PMID: 9873719]
Clinical Trial
分子量

284.34

Formula

C14H12N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nolatrexed 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nolatrexed147149-76-6AG 337AG337AG-337AntifolateInhibitorinhibitorinhibit

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目录号：
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