2. NF-κB
  3. Keap1-Nrf2
  4. Nrf2 activator-20

Nrf2 activator-20 是一种具有抗炎抗氧化活性，强效的 Nrf2 激活剂。Nrf2 activator-20 通过干扰 Keap1-Nrf2 之间的相互作用来激活抗炎途径，并且在体内具有有益效果。Nrf2 activator-20 可用于研究急性窘迫呼吸综合征 (ARDS) 和缺血再灌注损伤。

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Nrf2 activator-20

Nrf2 activator-20 Chemical Structure

CAS No. : 89883-16-9

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Nrf2 activator-20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nrf2 activator-20 is a potent Nrf2 activator with anti-inflammatory and antioxidant activities. Nrf2 activator-20 activates the anti-inflammatory pathway by interfering with the Keap1-Nrf2 interaction and is beneficial in vivo. Nrf2 activator-20 can be used for the study of acute respiratory distress syndrome (ARDS) and ischemia-reperfusion injury[1].

体外研究
(In Vitro)

Nrf2 activator-20 (Compound AP9) (1 μM, 2 h) 在 LPS (HY-D1056) 刺激和未刺激的 RAW 细胞中均能强烈激活 Nrf2 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nrf2 activator-20 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 1 μM
Incubation Time: 2 h
Result: Induced nuclear translocation of Nrf2 significantly while inducing HO-1 expression at nanomolar concentrations.
体内研究
(In Vivo)

Nrf2 activator-20 (Compound AP9) (0.78 mg/kg, i.p., 单次给药) 在肝缺血-再灌注损伤模型中显著缓解了小鼠的肝损伤[1]。
Nrf2 activator-20 (0.78 mg/kg, i.p., 单次给药) 在大肠杆菌诱导的肺损伤模型中改善了小鼠的肺损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Warm liver ischemia/reperfusion injury model established in C57BL/6J mice (9-14 weeks old, 27 g)[1]
Dosage: 0.78 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose prior to surgery
Result: Significantly reduced plasma ALT and AST as well as hepatocellular injury.
Animal Model: Lung injury model induced by E. coli treatment established in 11–12 week old male C57BL/6 mice[1]
Dosage: 0.78 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Improved oxygenation during E. coli-induced lung injury.
分子量

360.83

Formula

C7H5Br3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nrf2 activator-20 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2 activator-2089883-16-9Keap1-Nrf2ARDSanti-inflammationzebrafishischemia-reperfusion injurymiceInhibitorinhibitorinhibit

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