2. Stem Cell/Wnt
  3. Wnt
  4. NSC668036

NSC668036 是一种 Disheveled (Dvl) PDZ 结构域抑制剂，Kd 为 237 µM。NSC668036 通过中断 Frizzled-Dvl 相互作用来阻断 Wnt 信号。

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NSC668036 Chemical Structure

NSC668036 Chemical Structure

CAS No. : 144678-63-7

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规格 价格 是否有货 数量
1 mg ￥2181
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5 mg ￥4800
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NSC668036 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1].

体外研究
(In Vitro)

In Xenopus, NSC668036 inhibiteds the signaling induced by Wnt3A[1].
NSC668036 (10 μM) suppresses β-catenin-driven gene transcription and abolished TGF-β1-induced migration, expression of collagen I and α-smooth muscle actin (α-SMA) in fibroblasts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC668036 相关抗体:
体内研究
(In Vivo)

In Bleomycin-induced pulmonary fibrosis murine model, NSC668036 (5 mg/kg) significantly suppresses accumulation of collagen I, α-SMA, and TGF-β1 but increased the expression of CK19, Occludin and E-cadherin that can inhibit pulmonary fibrogenesis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

460.52

Formula

C21H36N2O9
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (259 KB) 元素分析报告 (205 KB)

产品使用指南 (1538 KB)
参考文献

NSC668036 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC668036144678-63-7NSC 668036NSC-668036WntDishevelledPDZFrizzledWnt signalingInhibitorinhibitorinhibit

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目录号：
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