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  2. Differentiation Inducing Compound Library

诱导分化化合物库 - Differentiation Inducing Compound Library

Cat. No.: HY-L038
Library Contents: XLSX PDF SDF

干细胞存在于所有的多细胞生物中,可以分裂和分化为各种特殊的细胞类型,并可以自我更新产生更多的干细胞。只有干细胞分化为临床所需要的细胞时,才能在疾病治疗中发挥作用,这一过程也称为诱导分化或定向分化。体内存在多种信号分子及蛋白家族可以对细胞分化产生影响,比如成纤维生长因子(FGFs),Wnt 蛋白家族,转化生长因子β(TGFβ)超家族以及骨形态发生蛋白(BMP)等。但是,目前使用重组细胞因子成本较高,大大限制了细胞因子在临床医学中的研究应用。由于小分子抑制剂使用成本较低,且无免疫原性,比细胞因子更具有研究潜力。小分子抑制剂可以通过激活或抑制特定的信号通路,建立与所需组织类型兼容的细胞来提高重编程效率。

MCE 诱导分化化合物库包含 877 种小分子化合物,这些化合物主要作用于细胞分化相关的信号通路,是诱导分化的潜在刺激物。MCE诱导分化化合物库是研究定向分化和再生医学的重要工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 诱导分化化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,858 个产品以 10 mM 浓度提供,19 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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50 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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2 × 100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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Please contact us at

sales@MedChemExpress.cn

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Description
& Advantages

•   A unique collection of 877 differentiation-inducing compounds for high throughput screening (HTS) and high content screening (HCS).

•   Stemness/Self-renewal pathway (such as Wnt/β-catenin, Hedgehog/Gli, Jagged/Notch) inhibitors and differentiation (BMP and retinoic acid (RA)) activators/agonists are included.

•   A useful tool for the induced differentiation study.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 877 compounds supplied as pre-dissolved Solutions or Solid
Solution: 858 compounds supplied in 10 mM solution, 19 compounds supplied in 2 mM solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

Differentiation Inducing Compound Library

Source: MedChem Express

Documentation

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    Differentiation Inducing Compound Library
    目录号:
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Storage Tubes with Rack