1. GPCR/G Protein Immunology/Inflammation
  2. CXCR
  3. NUCC-390

NUCC-390 是新型的选择性小分子 CXCR4 receptor 受体激动剂。NUCC-390 可以诱导 CXCR4 受体的内化,作用方式与 AMD3100 (HY-10046) 相反。NUCC-390 在动物模型中,有助于神经退行性变后神经功能恢复。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 NUCC-390 dihydrochloride 通常具有更好的水溶性和稳定性。

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NUCC-390 Chemical Structure

NUCC-390 Chemical Structure

CAS No. : 1060524-97-1

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Other Forms of NUCC-390:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献


NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046)[1][2]. NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo[2].

IC50 & Target[1]



(In Vitro)

NUCC-390 (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100[1].
NUCC-390 (10 μM; pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors[1].
NUCC-390 (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1].
NUCC-390 (0-1.25 μM; 24 hours) boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: C8161 cells 
Concentration: 10 μM
Incubation Time: Pre-treated 30 mins
Result: Increased the level of pERK.

Cell Proliferation Assay[2]

Cell Line: Cerebellar granule neurons (CGNs)
Concentration: 0 μM; 0.0625 μM; 0.25 μM; 1.25 μM
Incubation Time: 24 hours
Result: Stimulated axonal growth via CXCR4.
(In Vivo)

NUCC-390 (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six to eight-week-old CD1 mice[2]
Dosage: 3.2 mg/kg
Administration: Hind limb injection; twice daily; 3 days
Result: Promoted functional and anatomical recovery of the NMJ.





Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.


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