2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. ONO-9517601

ONO-9517601 是一种高效、具有口服活性、选择性强且可透过血脑屏障的 TREK-1/TREK-2 双重抑制剂 (TREK-1 IC50 = 0.067 μM，TREK-2 IC50 = 0.23 μM)。ONO-9517601 在 MK-801 (HY-15084B) 诱导的大鼠新物体识别 (NOR) 模型中表现出显著功效。ONO-9517601 可用于神经系统和认知障碍的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

ONO-9517601

ONO-9517601 Chemical Structure

CAS No. : 2640753-22-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

ONO-9517601 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ONO-9517601 is a potent, orally active, selective and CNS penetrant dual TREK-1/TREK-2 inhibitor (TREK-1 IC50= 0.067 μM, TREK-2 IC50= 0.23 μM). ONO-9517601 displays robust efficacy in an MK-801 (HY-15084B) challenge rat novel object recognition (NOR) paradigm. ONO-9517601 can be used for research on neurological and cognitive disorders[1].

IC50 & Target[1]

TREK-1

0.067 μM (IC50)

TREK-2

0.23 μM (IC50)

体外研究
(In Vitro)

ONO-9517601 (10 μM) 抑制腺苷 A3 (98%) 和 DAT (78%)，对 Cav1.2、HCN4、Kir2.1、Kv1.5、Kv4.3、KCNQ1/E1 和 Nav1.5 的活性极低，对 TASK-1、TASK-2、THIK-1 和 TRESK 没有显著影响，并且以 6.7 μM 的 IC50 阻断 hERG[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ONO-9517601 相关抗体:
药代动力学
(Parmacokinetics)[1]
Species Dose Route Indicator value
Rat 1 mg/kg i.v. CLplasma 30.0 mL/min/kg
Rat 1 mg/kg i.v. Vss 2.2 L/kg
Rat 1 mg/kg i.v. T1/2 1.0 h
Rat 1 mg/kg p.o. Cmax 80 ng/mL
Rat 1 mg/kg p.o. F 40 %
Cynomolgus Monkey 1 mg/kg p.o. Cmax 152 ng/mL
Cynomolgus Monkey 1 mg/kg p.o. F 34 %
Cynomolgus Monkey 1 mg/kg i.v. Vss 2.1 L/kg
Cynomolgus Monkey 1 mg/kg i.v. T1/2 3.3 h
Cynomolgus Monkey 1 mg/kg i.v. CLplasma 13.3 mL/min/kg
Dog 1 mg/kg p.o. Cmax 315 ng/mL
Dog 1 mg/kg p.o. F 97 %
Dog 1 mg/kg i.v. CLplasma 1.9 mL/min/kg
Dog 1 mg/kg i.v. Vss 5.9 L/kg
Dog 1 mg/kg i.v. T1/2 56 h
体内研究
(In Vivo)

ONO-9517601 (0.1-30 mg/kg，口服，在 MK-801 注射前 3.5 小时给药) 可改善 MK-801 诱导的认知功能障碍模型中大鼠的识别记忆[1]。
ONO-9517601 (56.6 mg/kg，口服，单次给药) 不会引起大鼠产生显著的神经行为学异常[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats[1]
Dosage: 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: p.o., 3.5 h pre-MK-801
Result: Significantly reversed the MK-801 deficit at 1, and 3 mg/kg. Improved recognition memory in rats.
分子量

461.94

Formula

C25H24ClN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ONO-9517601 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONO-95176012640753-22-4VU6022856ONO9517601ONO 9517601VU 6022856VU-6022856Potassium ChannelKcsApreclinical research toolsrobust efficacyion channel selectivityMK-801 challenge rat NOR paradigmKP family of potassium ion channelsCNS penetrantselective TREK inhibitionOPTimizationpotencyPK profilesTREK inhibitorsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ONO-9517601
目录号：
HY-179004
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z