2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species (ROS) NF-κB Apoptosis
  4. Opc 14117

OPC-14117 是一种口服有效且能穿过血脑屏障的超氧自由基清除剂。OPC-14117 抑制抑制氧化应激连锁反应，在脑挫伤模型中显著降低组织渗透压升高并减轻了脑水肿。OPC-14117 在 Quinolinic acid (HY-100807) 诱导的纹状体神经元凋亡 (apoptosis) 模型中阻断 NF-κB 依赖的凋亡途径。OPC-14117 可减少坏死体积、保护海马 CA3 神经元并恢复认知功能。OPC-14117 可用于研究继发性脑损伤和改善神经功能预后。

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Opc 14117

Opc 14117 Chemical Structure

CAS No. : 103233-65-4

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Opc 14117 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

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生物活性

OPC-14117 is an orally active superoxide radical scavenger that can cross the blood-brain barrier. OPC-14117 inhibits the oxidative stress cascade reaction, significantly reducing the increase in tissue osmotic pressure and alleviating brain edema in the brain contusion model. OPC-14117 blocks the NF-κB-dependent apoptotic pathway in the striatum neuron apoptosis model induced by Quinolinic acid (HY-100807). OPC-14117 can reduce the necrotic volume, protect hippocampal CA3 neurons and restore cognitive function. OPC-14117 can be used to study secondary brain injury and improve neurological prognosis[1][2].

分子量

437.57

Formula

C26H35N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Opc 14117 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Opc 14117103233-65-4Opc14117Opc-14117Reactive Oxygen Species (ROS)NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBCerebral contusionEdema formationTissue osmolalityCognitive behaviorFree radical scavengerRatInhibitorinhibitorinhibit

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