2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. OPC 33540

OPC-33540 是一种具有高选择性和竞争性的 PDE3 抑制剂，其 IC50 值为 0.32 nM (PDE3A) 和 1.5 nM (PDE3B)。OPC-33540 对 PDE1、PDE2、PDE4、PDE5 和 PDE7 的 IC50 值分别为 42.9、52.3、100.8、2.5 和 51.3 μM。OPC-33540 在血小板中能显著增强 cAMP积累并有效抑制凝血酶诱导的血小板聚集。OPC-33540 可用于抗血栓研究。

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OPC 33540

OPC 33540 Chemical Structure

CAS No. : 189362-27-4

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OPC 33540 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies[1].

IC50 & Target[1]

PDE3A

0.32 nM (IC50)

PDE3B

1.5 nM (IC50)

PDEI

42.9 μM (IC50)

PDE2

52.3 μM (IC50)

PDE4

100.8 μM (IC50)

PDE7

51.3 μM (IC50)

PDE5

2.5 μM (IC50)

体外研究
(In Vitro)

OPC-33540 (0.1-100 nM) 表现出浓度依赖性的血小板 cAMP 水平增加，并强烈抑制凝血酶诱导的血小板聚集[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OPC 33540 相关抗体:
分子量

469.62

Formula

C27H39N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OPC 33540 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OPC 33540189362-27-4OPC33540OPC-33540Phosphodiesterase (PDE)phosphodiesterase 3 inhibitorcilostamideplatelet aggregationcyclic AMPrecombinant enzymeInhibitorinhibitorinhibit

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目录号：
HY-112631
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