2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Oxyfedrine

Oxyfedrine，一种血管扩张剂，是一种具有口服活性的 β-肾上腺素受体 (β-adrenoreceptor) 激动剂。Oxyfedrine 可降低冠状血管的张力。Oxyfedrine 可用于心血管疾病的研究。

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Oxyfedrine Chemical Structure

Oxyfedrine Chemical Structure

CAS No. : 15687-41-9

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Other Forms of Oxyfedrine:

Oxyfedrine 相关抗体

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查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oxyfedrine, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine can be used in the research of cardiovascular disease[1][2].

IC50 & Target[1]

β-adrenoceptor

 

体外研究
(In Vitro)

Oxyfedrine (50 μM, 48 h) suppresses aldehyde dehydrogenase (ALDH) activity in HCT116 and HSC-4 cells[1].
Oxyfedrine (50 μM, 48 h) acts as a sensitizer for GSH-depleting agents, and induces cell death in HCT116 and HSC-4 cells when with the drug combinations[1].
Oxyfedrine (0-1 μg/mL) inhibits spontaneous myogenic activity in rat isolated portal vein[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oxyfedrine 相关抗体:
体内研究
(In Vivo)

Oxyfedrine (14 mg/kg, p.o., for 3-4 weeks) shows anti-anginal action in cats[2].
Oxyfedrine (10 mg/kg, i.p., HCT116 cell xenograft mice) suppresses tumor growth when combined with sulfasalazine (SSZ, 350 mg/kg, i.p.)[1].
Oxyfedrine (1 mg/kg, i.v.) decreases the arterial and venous blood high blood viscosity (HBV) in ice water stress rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cats[2]
Dosage: 14 mg/kg
Administration: Oral administration (p.o.), for 3-4 weeks.
Result: Decreased systolic and diastolic blood pressures, increased heart rate and cardiac output.
分子量

313.39

Formula

C19H23NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Oxyfedrine 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Oxyfedrine15687-41-9Adrenergic ReceptorBeta ReceptorAnti-anginalvesselcardiovascularblood viscosityALDHHCT116HSC-4GSHInhibitorinhibitorinhibit

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