2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. P-gp modulator-5

P-gp modulator-5 (compound 25) 是 P-gp 的调节剂，可抑制多药耐药性 (MDR) 肿瘤增殖。P-gp modulator-5 通过抑制 MDR 细胞中药物外排泵的活性，导致大量 ROS 积累和细胞周期谱改变。

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P-gp modulator-5

P-gp modulator-5 Chemical Structure

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P-gp modulator-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P-gp modulator-5 (compound 25) is a modulator of P-gp and can inhibit the proliferation of multidrug resistant (MDR) tumors. P-gp modulator-5 inhibits the activity of drug efflux pumps in MDR cells, leading to a large accumulation of ROS and altered cell cycle profiles[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
0.22 μM
Compound: 25
Inhibition of human A549 cells incubated for 48 hrs by SRB method
Inhibition of human A549 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
COLO 205 GI50
0.16 μM
Compound: 25
Inhibition of cell growth in human COLO 205 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human COLO 205 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
DLD-1 GI50
0.61 μM
Compound: 25
Inhibition of cell growth in human DLD-1 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human DLD-1 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
H322 GI50
0.174 μM
Compound: 25
Inhibition of human H322 cells incubated for 48 hrs by SRB method
Inhibition of human H322 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
K562 GI50
0.25 μM
Compound: 25
Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
LOX IMVI GI50
0.19 μM
Compound: 25
Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB method
[PMID: 39093920]
MCF7 GI50
0.15 μM
Compound: 25
Inhibition of cell growth in human MCF7 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human MCF7 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
MRC5 GI50
1.53 μM
Compound: 25
Cytotoxicity against human MRC5 cells incubated for 48 hrs by SRB method
Cytotoxicity against human MRC5 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
NCI-H460 GI50
0.35 μM
Compound: 25
Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
NCI/ADR-RES GI50
0.23 μM
Compound: 25
Inhibition of cell growth in human NCI-ADR-RES cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human NCI-ADR-RES cells incubated for 48 hrs by SRB method
[PMID: 39093920]
OVCAR-3 GI50
0.048 μM
Compound: 25
Inhibition of cell growth in human OVCAR-3 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human OVCAR-3 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
OVCAR-8 GI50
0.24 μM
Compound: 25
Inhibition of cell growth in human OVCAR-8 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human OVCAR-8 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
UACC-62 GI50
0.16 μM
Compound: 25
Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB method
[PMID: 39093920]
分子量

352.34

Formula

C19H16N2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P-gp modulator-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp modulator-5P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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目录号：
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