2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation Anti-infection
  3. Phosphodiesterase (PDE) TNF Receptor NO Synthase Bacterial
  4. PDE4-IN-28

PDE4-IN-28 是一种 PDE4D 抑制剂 (IC50: 29 nM)。PDE4-IN-28 可抑制 TNF-α 和 NO 的产生 (IC50 分别为 13.32 和 2.32 μM)。PDE4-IN-28 在大鼠压疮 (PU) 模型中具有抗炎、抗菌和镇痛作用，并促进 HUVEC 细胞迁移，从而加速伤口愈合。

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PDE4-IN-28 Chemical Structure

PDE4-IN-28 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

PDE4-IN-28 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDE4-IN-28 is a PDE4D inhibitor (IC50: 29 nM). PDE4-IN-28 inhibits the production of TNF-α and NO (IC50: 13.32 and 2.32 μM, respectively). PDE4-IN-28 exhibits anti-inflammatory, antibacterial and analgesic effects in a rat pressure ulcer (PU) model and promotes HUVEC cell migration, thereby accelerating wound healing[1].

IC50 & Target[1]

PDE4D

29 nM (IC50)

分子量

623.57

Formula

C28H27F2N9O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PDE4-IN-28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE4-IN-28Phosphodiesterase (PDE)TNF ReceptorNO SynthaseBacterialTumor Necrosis Factor ReceptorTNFRNitric oxide synthasesNOSPressure ulcers (PU)anti-inflammatoryantibacterialanalgesicHUVECRaw264.7 cellInhibitorinhibitorinhibit

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产品名称：
PDE4-IN-28
目录号：
HY-176234
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