2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Apolipoprotein DNA/RNA Synthesis
  4. Pelacarsen sodium

Pelacarsen sodium  (Synonyms: AKCEA-APO(a)-LRx sodium; ISIS 681257 sodium; TQJ230 sodium)

目录号: HY-151123A 纯度: 92.70%
COA 产品使用指南 技术支持

Pelacarsen sodium (ISIS 681257 sodium) 是一种 GalNAc3 偶联的 2′-MOE 修饰的反义寡核苷酸 (antisense oligonucleotide)。Pelacarsen sodium 可减少 apo (a)。

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DNA, d([2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rC-m5C-sp-G-sp-T-sp-T-sp-G-sp-G-sp-T-sp-G-sp-m5C-sp-T-sp-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]m5rC), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate], sodium salt

Pelacarsen sodium Chemical Structure

CAS No. : 2172851-58-8

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规格 价格 是否有货 数量
1 mg ￥1480
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5 mg ￥3960
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10 mg ￥5220
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Customer Review

Other Forms of Pelacarsen sodium:

Pelacarsen sodium 相关抗体

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apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a)[1][2][3].

体外研究
(In Vitro)

Pelacarsen (5-150 μg/mL) sodium 与小鼠血浆蛋白的结合率很高，在 5 μg/mL 和 150 μg/mL 时分别为 96.3% 和 94.1%[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pelacarsen sodium 相关抗体:
体内研究
(In Vivo)

Pelacarsen (0.3-10 mg/kg；皮下注射；每周一次；6 周) sodium 可降低人 LPA 转基因小鼠肝脏载脂蛋白 (a) mRNA和血浆载脂蛋白 (a) 蛋白水平，其效力比未结合的 ISIS 494372高出 20 多倍[2]。
Pelacarsen (1-12 mg/kg；皮下注射) sodium 在食蟹猴体内吸收迅速[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human LPA transgenic mice[2]
Dosage: 0.3, 1, 3, 10 mg/kg
Administration: Subcutaneous injection, once weekly, 6 weeks
Result: Showed dose-dependent reductions in liver apo(a) mRNA and plasma apo(a) protein levels.
Showed ED50 values of 0.32 mg/kg/week and 0.54 mg/kg/week for liver apo(a) mRNA and plasma apo(a) protein, respectively.
Animal Model: CD-1 mice[2]
Dosage: 4, 40, 140 mg/kg
Administration: Subcutaneous injection, loading doses on days 1, 3, 5, 7, then once weekly thereafter, up to 28 days
Result: Distributed rapidly to liver and kidney.
Showed a tissue elimination half-life of 6-9 days.
Clinical Trial
分子量

9076.00

Formula

C296H419N71Na20O163P20S13
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 92.70%

COA (285 KB) RP-HPLC (213 KB)

产品使用指南 (1538 KB)
参考文献

Pelacarsen sodium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pelacarsen2172851-58-8AKCEA-APO(a)-LRxISIS 681257TQJ230ISIS681257ISIS-681257TQJ 230TQJ-230ApolipoproteinDNA/RNA Synthesiscardiovascular diseaseslipoprotein disorderschronic kidney diseaseantisense oligonucleotideInhibitorinhibitorinhibit

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