2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Phenylacetic acid mustard

Phenylacetic acid mustard 是化疗试剂 Chlorambucil (HY-13593) 的主要代谢产物 (metabolite)。Chlorambucil 是一种烷化剂 (alkylator)，具有抗肿瘤活性。

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Phenylacetic acid mustard Chemical Structure

Phenylacetic acid mustard Chemical Structure

CAS No. : 10477-72-2

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规格 是否有货
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Customer Review

Phenylacetic acid mustard 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity[1].

IC50 & Target

IC50: metabolite of Chlorambucil[1]
体内研究
(In Vivo)

Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than CHL, it exhibits an ED15 value of 8.0 mg/kg[2].
Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Inbred male C3H/He mice[1]
Dosage: 0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration: Intraperitoneal injection; 15 days
Result: Exhibited anti-tumor activities in vivo.
分子量

276.16

Formula

C12H15Cl2NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    Phenylacetic acid mustard (PAAM) is dissolved in acidified ethanol (4.8 ml cone HC1 and 95% v/v ethyl alcohol in a volume of 100 ml) and diluted 1:9 with propylene glycol/K2HPO 4 buffer (20 g K2HPO4 plus 450 ml propylene glycol), final pH 7.4[2].

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Phenylacetic acid mustard 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenylacetic acid mustard10477-72-2DNA Alkylator/CrosslinkerchemotherapeuticagentmetaboliteantitumorInhibitorinhibitorinhibit

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产品名称：
Phenylacetic acid mustard
目录号：
HY-136327
需求量：

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