2. JAK/STAT Signaling
  3. Pim
  4. Pim-1 kinase inhibitor 4

Pim-1 kinase inhibitor 4 (Compound 10f) 是一种 Pim-1 激酶 抑制剂 (IC50: 17.01 nM)。Pim-1 kinase inhibitor 4 还具有抗氧化活性并抑制 DPPH。Pim-1 kinase inhibitor 4 诱导 PC-3 细胞凋亡 (apoptosis)，并抑制 PC-3 细胞生长，IC50 为 16 nM。apoptosis 可用于前列腺癌研究。

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Pim-1 kinase inhibitor 4

Pim-1 kinase inhibitor 4 Chemical Structure

CAS No. : 3026670-71-0

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Pim-1 kinase inhibitor 4 相关抗体

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PIM1 PIM2 PIM3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC50: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC50 of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
0.13 μM
Compound: 10f
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 36848846]
MCF7 IC50
5.37 μM
Compound: 10f
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 36848846]
PC-3 IC50
0.016 μM
Compound: 10f
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 36848846]
分子量

333.77

Formula

C19H12ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pim-1 kinase inhibitor 4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pim-1 kinase inhibitor 43026670-71-0PimPim kinasesProstate cancerDPPHantioxidantPC-3Inhibitorinhibitorinhibit

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