1. TGF-beta/Smad
  2. TGF-β Receptor
  3. pm26TGF-β1 peptide

pm26TGF-β1 peptide 是一种模拟人 TGF-β1 分子的肽,并对 TGF-β1 受体具有高亲和力。pm26TGF-β1 peptide 具有有效的抗炎特性,并且不表现出嗜中性粒细胞的趋化性。

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Custom Peptide Synthesis

pm26TGF-β1 peptide Chemical Structure

pm26TGF-β1 peptide Chemical Structure

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pm26TGF-β1 peptide 的其他形式现货产品:

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Other Forms of pm26TGF-β1 peptide:

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Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 TGF-β Receptor 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction[1][2].

IC50 & Target

TGF-β1 receptor[1][2]

体外研究
(In Vitro)

The synthetic pm26TGF-β1 peptide (1 μM, 10 μM and 100 μM; 24-48 hours) tested in peripheral blood mononuclear cells (PBMC) significantly down-modulates TNF-α and up-regulates IL-10 responses in an inflammatory microenvironment, leading to regulatory T cells (Treg) phenotype differentiation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

pm26TGF-β1 peptide (100-1000 µg/kg; subcutaneous injection; once; male C57BL/6 mice) treatment decreases neutrophils migration during inflammatory process in C57BL/6 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (5-7-weeks old; 20-30g) injected with carrageenan[1]
Dosage: 100 µg/kg, 300 µg/kg or 1000 µg/kg
Administration: Subcutaneous injection; once
Result: Decreased neutrophils migration during inflammatory process in C57BL/6 mice.
分子量

1392.56

Formula

C54H93N19O20S2

Sequence

Ala-Cys-Glu-Ser-Pro-Leu-Lys-Arg-Gln-Cys-Gly-Gly-Gly-Ser

Sequence Shortening

ACESPLKRQCGGGS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

pm26TGF-β1 peptide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
pm26TGF-β1 peptide
目录号:
HY-P2294
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