2. Epigenetics
  3. Epigenetic Reader Domain
  4. PROTAC_ERRα

PROTAC_ERRα 是一种有效的选择性 ERRα 降解剂。PROTAC_ERRα 诱导蛋白酶体降解，并且能够特异性降解 ERRα 蛋白 >80%。

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PROTAC_ERRα Chemical Structure

PROTAC_ERRα Chemical Structure

CAS No. : 1801547-15-8

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PROTAC_ERRα 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC_ERRα is a potent and selective ERRα degrader. PROTAC_ERRα induces proteasomal degradation and has capable of specifically degrading ERRα protein by >80%[1].

体外研究
(In Vitro)

PROTAC_ERRα (0-1000 nM; 8 hours; MCF7 cells) down-regulates ERRα protein levels in a dose-dependent fashion[1].
PROTAC_ERRα (100-500 nM; 4-24 hours; MCF7 cells) possesses good selectivity for ERRα target and decreases protein levels of ERRα downstream target genes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC_ERRα 相关抗体:

Western Blot Analysis[1]

Cell Line: MCF7 cells
Concentration: 0, 10, 30, 100, 300 and 1000 nM
Incubation Time: 8 hours
Result: Decreased in ERRα level in a dose-dependent fashion and the maximal level of degradation (D50) is 86%.
体内研究
(In Vivo)

PROTAC_ERRα (100 mg/kg; i.p.; every eight hours) degrades ERRα level in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection ; every eight hours.
Result: Reduced ERRα levels in mouse heart and kidney and MDA-MB-231 tumors by approximately 44%, 44% and 39%, respectively.
分子量

949.03

Formula

C46H47F3N6O9S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC_ERRα 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC_ERRα1801547-15-8Epigenetic Reader DomainERRαproteasomaldegraderInhibitorinhibitorinhibit

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产品名称：
PROTAC_ERRα
目录号：
HY-147174
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