2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. Protriptyline

Protriptyline 是一种强效三环类抗抑郁剂 (TCA)。Protriptyline 可抑制乙酰胆碱酯酶 (AChE) 活性，IC50 值为 0.06 mM，并抑制 Aβ 自组装。Protriptyline 可用于抑郁症和阿尔茨海默病的研究。

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Protriptyline

Protriptyline Chemical Structure

CAS No. : 438-60-8

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Protriptyline 的其他形式现货产品:

Customer Review

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Protriptyline 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease[1][2][3].

IC50 & Target[1]

AChE

0.06 mM (IC50)

体外研究
(In Vitro)

Protriptyline (0-70 μM；24 小时；PC3 细胞) 在 PC3 细胞中引起细胞毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Protriptyline 相关抗体:

Cell Cytotoxicity Assay[2]

Cell Line: PC3 cells
Concentration: 50, 60 and 70 μM
Incubation Time: 24 hours
Result: Decreased cell viability in a concentration-dependent manner.
体内研究
(In Vivo)

Protriptyline (10 mg/kg；腹腔注射；21 天；AD 大鼠模型) 改善 STZ 处理大鼠的空间学习和保留记忆[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model of AD[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; for 21 days.
Result: Reduced pTau, Aβ42 and BACE-1 levels, neurodegeneration, oxidative stress and glial activation. Improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFκB and GFAP expression.
Clinical Trial
分子量

263.38

Formula

C19H21N
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Protriptyline 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protriptyline438-60-8Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaalzheimersAβ Self-AssemblyAChEInhibitorinhibitorinhibit

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目录号：
HY-B0949A
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