2. Metabolic Enzyme/Protease NF-κB
  3. Endogenous Metabolite Keap1-Nrf2 NF-κB
  4. Pyrraline

Pyrraline 是一种能激活 Nrf2 通路激活剂，具有抗氧化和抗炎作用。Pyrraline 通过激活抗氧化反应元件 (ARE) 来上调抗氧化酶，如 NAD(P)H 氧化酶 (NQO1) 和血红素加氧酶-1 (HO-1)，同时抑制由 NFκB 介导的炎症反应。Pyrraline 有望用于代谢紊乱 (如糖尿病肾病) 和癌症的研究。

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Pyrraline

Pyrraline Chemical Structure

CAS No. : 74509-14-1

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1 mg ￥3600
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Pyrraline 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers[1][2].

分子量

254.28

Formula

C12H18N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pyrraline 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyrraline74509-14-1Endogenous MetaboliteKeap1-Nrf2NF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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