2. NF-κB PI3K/Akt/mTOR
  3. NF-κB Akt
  4. (rac)-AG-205

(rac)-AG-205 是一种有效的孕激素受体膜组分1 (Pgrmc1)抑制剂，可以诱导参与甾醇合成的基因，包括与 PGRMC1 形成复合物的 INSIG1 蛋白。(rac)-AG-205 可以通过阻止 NF-kB 信号和 BDNF/PI3K/AKT 通路的激活来阻止神经元对缺氧缺血的抵抗。

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(rac)-AG-205 Chemical Structure

(rac)-AG-205 Chemical Structure

CAS No. : 442656-02-2

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规格 价格 是否有货 数量
5 mg ￥3953
3 - 4 周
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(rac)-AG-205 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1].

分子量

454.98

Formula

C22H23ClN6OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(rac)-AG-205 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rac)-AG-205442656-02-2NF-κBAktNuclear factor-κBNuclear factor-kappaBPKBProtein kinase BPgrmc1INSIG1NF-kBneuronal resistanceInhibitorinhibitorinhibit

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