2. Anti-infection
  3. Antibiotic Bacterial
  4. Ranbezolid

Ranbezolid  (Synonyms: RBx7644 free base)

目录号: HY-19428
产品使用指南 技术支持

Ranbezolid (RBx7644 free base) 是一种口服有效的，针对革兰式阳性和革兰式阴性厌氧菌 (如金黄色葡萄球菌、表皮葡萄球菌、脆弱拟杆菌) 的恶唑烷酮类抗生素 (antibiotic)。Ranbezolid 可抑制 50s 核糖体亚基，其对于细菌核糖体的 IC50 值为 17 μM。Ranbezolid 还可干扰其细胞壁和脂质合成。Ranbezolid 可快速杀菌，显著降低细菌负荷，且具备更好的心血管安全性。Ranbezolid 可用于厌氧菌抗生素的研究。

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Ranbezolid

Ranbezolid Chemical Structure

CAS No. : 392659-38-0

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Ranbezolid 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ranbezolid (RBx7644 free base) is an orally active, oxazolidinone antibiotic against Gram-positive and Gram-negative anaerobes including Staphylococcus aureus, Staphylococcus epidermidis and Bacteroides fragilis. Ranbezolid can inhibit the 50s ribosomal subunit with an IC50 of 17 μM for bacterial ribosomes. Ranbezolid interferes cell wall and lipid synthesis. Ranbezolid can rapidly kill bacteria, significantly reduce bacterial load, and has better cardiovascular safety. Ranbezolid can be used for the study of antibiotics for anaerobic bacteria[1][2][3].

体外研究
(In Vitro)

Ranbezolid (1 μg/mL) 能够强效抑制金黄色葡萄球菌和表皮葡萄球菌蛋白质合成，并且额外抑制表皮葡萄球菌的细胞壁和脂质合成[1]。
Ranbezoild (1-8 μg/mL) 能够浓度依赖型引起表皮葡萄球菌的膜损伤[1]。
Ranbezoild 对于细菌核糖体的 IC50 值为 17 μM，安全性指数为 865[1]。
Ranbezolid 针对脆弱拟杆菌、普通拟杆菌、多形拟杆菌、产气荚膜梭菌、艰难梭菌和马格纳斯菌的最小抑菌浓度 (MIC) 分别为 0.06、0.015、0.06、0.06、0.03 和 0.015 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ranbezolid 相关抗体:
体内研究
(In Vivo)

Ranbezoild (100 mg/kg, p.o., 每日给药 2 次, 共 5 天) 在小鼠异物感染模型中，对脆弱拟杆菌具有出色的体内活性[2]。
Ranbezoild (≤ 50 mg/kg, p.o., 单次给药) 在大鼠自发升压模型中不会显著增强 Tyramine (HY-W007606) 引发的升压反应[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine foreign-body infection with Bacteroides fragilis established in swiss albino mice of either sex weighing 20 g[2]
Dosage: 100 mg/kg
Administration: Oral administration (p.o.), twice daily, for 5 days
Result: Displayed 5.39log10 reductions.
Animal Model: Pressor response model established in male Wistar rats (250-350 g)[3]
Dosage: 15, 50 and 100 mg/kg
Administration: Oral administration (p.o.), single dose
Result: Increased mean arterial pressure by 10, 11, 14 mm Hg (15, 50 and 100 mg/kg) with 5 mg/kg Tyramine (HY-W007606).
分子量

461.44

Formula

C21H24FN5O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ranbezolid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ranbezolid392659-38-0RBx7644RBx 7644RBx-7644AntibioticBacterialCABPStaphylococcus aureusStaphylococcus epidermidisStreptococcus pneumoniaeHaemophilus influenzaeantibacterialInhibitorinhibitorinhibit

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