2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Cytochrome P450
  4. RB-90740

RB-90740 是一种生物还原剂。RB-90740 在细胞内 (通常是低氧环境下) 通过代谢还原被激活，生成具有细胞毒性的产物，从而选择性杀伤肿瘤细胞。RB-90740 对缺氧细胞具有选择性的毒性，该毒性主要通过引起 DNA 链断裂、激活还原酶 (如细胞色素 P450 还原酶 (Cytochrome P450)) 实现。RB-90740 在小鼠模型中的缺氧细胞并未先出如体外性质一般的细胞毒性。RB-90740 可用于研究肿瘤生理学环境。

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RB-90740

RB-90740 Chemical Structure

CAS No. : 108307-65-9

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     可免费申领三个不同产品的试用装。

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RB-90740 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RB-90740 is a type of biological reducing agent. RB-90740 is activated through metabolic reduction and generates cytotoxic products, thereby selectively killing tumor cells (usually in a hypoxic environment). RB-90740 has selective toxicity towards hypoxic cells, which is mainly achieved by causing DNA strand breaks and activating reducing enzymes (such as Cytochrome P450). RB-90740 does not initially exhibit cytotoxicity similar to its in vitro properties in hypoxic cells in mouse models. RB-90740 can be used to study the tumor physiological environment[1][2]

分子量

362.43

Formula

C20H22N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RB-90740 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RB-90740108307-65-9RB90740RB 90740DNA/RNA SynthesisCytochrome P450CYPsBioreductive DrugsTumor HypoxiaHypoxic CytotoxinsTumor SelectivityReductase Enzymes (DT-diaphoraseCytochrome P450 reductase)Inhibitorinhibitorinhibit

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产品名称：
RB-90740
目录号：
HY-118722
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