Galectin-1/LGALS1 蛋白, Rat

Galectin-1/LGALS1 protein is a β-galactoside-binding lectin that regulates apoptosis, cell proliferation and differentiation by inhibiting CD45 protein phosphatase activity and preventing Lyn kinase dephosphorylation. As a homodimer, it induces T cell apoptosis and interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM, CD45, laminin, and SUSD2. Galectin-1/LGALS1 Protein, Rat is the recombinant rat-derived Galectin-1/LGALS1 protein, expressed by E. coli , with tag free. The total length of Galectin-1/LGALS1 Protein, Rat is 134 a.a., with molecular weight of ~13 kDa.

Galectin-1/LGALS1 蛋白是一种凝集素，对结合 β-半乳糖苷和多种复杂碳水化合物具有高亲和力。该蛋白在细胞凋亡、细胞增殖和细胞分化的调节中起着至关重要的作用。值得注意的是，它抑制 CD45 蛋白磷酸酶的活性，从而防止 Lyn 激酶去磷酸化。Galectin-1/LGALS1 是 T 细胞凋亡的有效诱导剂。它以同二聚体形式存在，与多种蛋白质形成相互作用，包括 CD2、CD3、CD4、CD6、CD7、CD43、ALCAM 和 CD45。此外，Galectin-1/LGALS1 通过聚-N-乙酰基乳糖胺结合与层粘连蛋白相互作用，并与 SUSD2 结合。此外，它与货物受体 TMED10 发生显着的相互作用，促进从细胞质易位到内质网-高尔基中间室 (ERGIC) 和随后的分泌。

Rat

E. coli

Tag Free

P11762 (A2-E135)

56646  [NCBI]

ACGLVASNLNLKPGECLKVRGELAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDDGTWGTEQRETAFPFQPGSITEVCITFDQADLTIKLPDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE

Approximately 13 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.