HGFR 蛋白, Cynomolgus/Rhesus Macaque (HEK293, His)

HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque, cynomolgus-derived HGFR protein, expressed by HEK293 , with C-His labeled tag. The total length of HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is 932 a.a., with molecular weight of ~128.2 & 77.6 & 45.7 kDa, respectively.

肝细胞生长因子受体 (HGFR) 是一种受体酪氨酸激酶，通过与肝细胞生长因子/HGF 配体结合，充当细胞外基质的信号转导器。它在调节多种生理过程中发挥着关键作用，包括增殖、散射、形态发生和细胞存活。配体在细胞表面结合后，HGFR 在其胞内结构域上发生自磷酸化，为下游信号分子创建对接位点。被配体激活后，它与 PI3 激酶亚基 PIK3R1、PLCG1、SRC、GRB2、STAT3 或适配器 GAB1 相互作用，导致多个信号级联的激活，包括 RAS-ERK、PI3 激酶-AKT 和 PLCgamma-PKC。RAS-ERK 激活与形态发生效应相关，而 PI3K/AKT 协调促生存效应。在胚胎发育中，HGFR 信号传导有助于原肠胚形成、神经元前体的发育和迁移、血管生成和肾脏形成。在骨骼肌发育过程中，它对于肌肉祖细胞的迁移和次级成肌细胞的增殖至关重要。在成人中，它参与伤口愈合、器官再生、组织重塑，并促进造血细胞的分化和增殖。此外，在微生物感染的情况下，HGFR 作为 InlB 内单核细胞增生李斯特菌的受体，介导病原体进入细胞^[1][2][3]。

Rhesus Macaque; Cynomolgus

HEK293

C-His

NP_001162100.1 (M1-T932)

704562  [NCBI]

MKAPAVLVPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETAIQNVILHEH HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPNQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPHHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE FRDSYPIKYIHAFESNNFIYFLTVQRETLNAQTFHTRIIRFCSLNSGLHSYMEMPLECIL TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRAEF TTALQRVDLFMGQFSEVLLTSISTFVKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL LDSHPVSPEVIVEHPLNQNGYTLVVTGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW CHDKCVRSEECPSGTWTQQICLPAIYKVFPTSAPLEGGTRLTICGWDFGFRRNNKFDLKK TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPIIT SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLHSVSVPRMVINVH EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL LKLNSELNIEWKQAISSTVLGKVIVQPDQNFT

Approximately 128.2&77.6&45.7 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.