2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. REGN7999

REGN7999 是一种抑制 TMPRSS6 的单克隆抗体。REGN7999 可抑制 TMPRSS6 活性，防止 HJV 裂解，从而增强 BMP6-HJV 信号传导，增加血清铁调素。REGN7999 通过抑制 TMPRSS6 活性改善地中海贫血 β 小鼠模型的铁过载和红细胞生成受损。REGN7999 可用于 β-地中海贫血的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

REGN7999

REGN7999 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

REGN7999 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

REGN7999 is a monoclonal antibody that inhibits TMPRSS6. REGN7999 inhibits TMPRSS6 activity, preventing Hemojuvelin (HJV) lysis, thereby enhancing BMP6-HJV signaling and increasing serum hepcidin. REGN7999 ameliorates iron overload and impaired erythropoiesis in a β-thalassemia mouse model by inhibiting TMPRSS6 activity. REGN7999 is indicated for research in β-thalassemia[1][2].

反应种属

Human
IC50 & Target

TMPRSS6
体外研究
(In Vitro)

REGN7999 在过表达 HJV 和 TMPRSS6 的 HEK293 细胞中可阻断人类和小鼠 TMPRSS6 的活性，IC50 分别为 0.68 和 16 nM，并可阻止 HJV 裂解[2]。
REGN7999 可结合 TMPRSS6 并抑制跨物种的 TMPRSS6 活性，降低人类参考和变体 TMPRSS6、食蟹猴 TMPRSS6 以及小鼠 TMPRSS6 的蛋白水解活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

REGN7999 相关抗体:
体内研究
(In Vivo)

REGN7999 (10 mg/kg，皮下注射，每周一次，共 12 周) 在 Hbbth3/+ 小鼠模型中可提高血清铁调素水平，降低肝铁含量，恢复红细胞 (RBC) 水平，并改善红细胞健康[1][2]。
REGN7999 (5 mg/kg，皮下注射，一次) 可增加 C57BL/6 小鼠模型中的血清铁调素并降低血清铁[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hbbth3/+ mice model[1][2]
Dosage: 10 mg/kg
Administration: s.c., once a week, 12 weeks
Result: Reduced liver iron (~50% reduction compared to the isotype-treated group), improved RBC health as determined by reduced annexin V staining and RBC turnover, extend the RBC life span.
Elevated serum hepcidin and hepatic HAMP1 expression, did not increase markers of liver damage.
Reduced spleen weights to WT levels, displayed normalized reticulocyte numbers, blunted the increase in oxidative stress in blood and spleens, reduced bilirubin levels and lower expression levels of hepatic Hmox1, improved anaerobic capacity, increased bone mineral density.
Animal Model: C57BL/6 mice model[2]
Dosage: 5 mg/kg
Administration: s.c., once
Result: Increased serum hepcidin, and decreased in serum iron, led to a significant drop of transferrin saturation and serum iron in the first 24 hours.
基因 ID

164656  [NCBI]

Accession
靶点

TMPRSS6
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

REGN7999 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

REGN7999REGN 7999REGN-7999Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesmonoclonal antibodyβ-thalassemiaHEK293 cellsHbbth3/+ mice modelInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
REGN7999
目录号：
HY-P991637
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z