1. Membrane Transporter/Ion Channel Immunology/Inflammation
  2. CRAC Channel Interleukin Related
  3. RO2959 hydrochloride

RO2959 hydrochloride 是一种有效的选择性 CRAC 通道抑制剂,IC50 为 402 nM。RO2959 hydrochloride 是由 Orai1/Stim1 通道介导的钙存储进入 (SOCE) 的有效阻滞剂,IC50 为 25 nM。RO2959 hydrochloride 还是人 IL-2 产生的有效抑制剂,有效阻断 T 细胞受体触发的基因表达和 T 细胞功能途径。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

RO2959 hydrochloride Chemical Structure

RO2959 hydrochloride Chemical Structure

CAS No. : 1219927-22-6

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货
1 mg ¥1333
询问价格 & 货期
5 mg ¥3500
询问价格 & 货期

* Please select Quantity before adding items.

RO2959 hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of RO2959 hydrochloride:

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2].

IC50 & Target[1]

IL-2

 

CRAC channel

402 nM (IC50)

Orai1/Stim1 channels

25 nM (IC50)

体外研究
(In Vitro)

RO2959 inhibits Orai1 and Orai3 with IC50 values of 25 nM and 530 nM, respectively. RO2959 blocks store operated calcium entry (SOCE) in activated CD4+T lymphocytes with an IC50 value of 265 nM[1].
RO2959 is a potent SOCE inhibitor that blocks an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either T cell receptor (TCR) stimulation or thapsigargin treatment. RO2959 completely inhibits cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Formula

C21H19F2N5OS.xHCl

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
RO2959 hydrochloride
目录号:
HY-113618A
需求量: