1. GPCR/G Protein Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. Rocatinlimab

Rocatinlimab  (Synonyms: 诺卡替利单抗; AMG 451; KHK4083)

目录号: HY-P99955 纯度: 99.95%
COA 技术支持

Rocatinlimab (AMG 451) (KHK4083) 是一种全人源、非岩藻糖基化的免疫球蛋白 G1 (IgG1) 抗 OX40 单克隆抗体。 Rocatinlimab 可用于特应性皮炎 (AD) 的研究。

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CAS No. : 2431972-52-8

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规格 价格 是否有货 数量
1 mg ¥3500
In-stock
5 mg ¥9100
In-stock
10 mg   询价  
50 mg   询价  

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查看 Orexin Receptor (OX Receptor) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated, immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD)[1].

同型

Human IgG1 kappa

推荐同型对照抗体
种属

Human

体外研究
(In Vitro)

OX40(也称为 CD134 或 TNFRSF4)是一种共刺激因子,在免疫反应中发挥重要作用。OX40 是肿瘤坏死因子受体(TNFR)超家族的一员,是 T 细胞的重要调节因子。OX40 在增强对肿瘤的免疫反应或调节自身免疫疾病中的免疫活性方面具有显著的治疗潜力。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

144.618 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

诺卡替利单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Biological Activity
  • Loaded OX40/TNFRSF4 Protein, Human (HEK293, Fc, HY-P70813) on SA biosensor, can bind Rocatinlimab with an affinity constant of 3.012E-10 M as determined in BLI assay.
  • Immobilized Human OX40/TNFRSF4 Protein (ECD, His Tag) can bind Rocatinlimab. The EC50 for this effect is 2.003 ng/mL.
纯度 & 产品资料

纯度: 99.95%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Rocatinlimab
目录号:
HY-P99955
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