1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-C6-NH2 hydrochloride

(S,R,S)-AHPC-C6-NH2 hydrochloride (Synonyms: VH032-C6-NH2 hydrochloride)

目录号: HY-136006A
产品使用指南

(S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C6-NH2 hydrochloride) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 VH032 的 VHL 配体和 1 个 linker。(S,R,S)-AHPC-C6-NH2 hydrochloride 可用于合成靶向 AKT的 PROTAC 降解剂,例 6,XF038-161A,源于专利文献 WO2019173516A1。

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(S,R,S)-AHPC-C6-NH2 hydrochloride Chemical Structure

(S,R,S)-AHPC-C6-NH2 hydrochloride Chemical Structure

CAS No. : 2360522-76-3

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Description

(S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C6-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 hydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1[1].

IC50 & Target[1]

VHL

 

In Vitro

(S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C5-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader, XF038-161A, example 6, extracted from patent WO2019173516A1[1].

Molecular Weight

594.21

Formula

C₂₉H₄₄ClN₅O₄S

CAS No.

2360522-76-3

SMILES

[H]Cl.O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCN)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

(S,R,S)-AHPC-C6-NH2VH032-C6-NH2E3 Ligase Ligand-Linker ConjugateAKTdegradationXF038-161APROTACrheumatoid arthritisosteoarthritisCrohn’sdiseaseangiofibromaretinalvascularizationdiabetic retinopathyInhibitorinhibitorinhibit

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产品名称:
(S,R,S)-AHPC-C6-NH2 hydrochloride
目录号:
HY-136006A
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