2. Neuronal Signaling
  3. Tau Protein
  4. Sabeluzole

Sabeluzole  (Synonyms: R 58735)

目录号: HY-105022
产品使用指南

摩尔计算器

Sabeluzole (R 58735) 是一种苯并噻唑衍生物，具有抗缺血、抗癫痫和增强认知的特性。Sabeluzole 通过阻止 tau 表达保护大鼠海马神经元免受 NMDA 和谷氨酸诱导的神经毒性。Sabeluzole 增强大鼠的记忆力，并防止 Chlordiazepoxide 的遗忘效应。Sabeluzole 可用于阿尔茨海默病研究。

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Sabeluzole Chemical Structure

Sabeluzole Chemical Structure

CAS No. : 104383-17-7

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规格 价格 是否有货 数量
5 mg ￥1687
3 - 4 周
10 mg   询价  
50 mg   询价  

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Customer Review

Sabeluzole 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease[1][2].

体外研究
(In Vitro)

Sabeluzole（50 nM、100 nM；细胞损伤前 20 分钟）在小脑颗粒细胞原代培养物中对谷氨酸 (50 μM) 介导的兴奋性毒性具有保护作用[1]。
Sabeluzole（50 nM；7 天）抑制谷氨酸诱导的 tau 蛋白水平增加[1]。
Sabeluzole（50 nM; 4 d）在人神经母细胞瘤细胞系 SH-SY5Y 中表现出神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sabeluzole 相关抗体:
体内研究
(In Vivo)

Sabeluzole（5 mg/kg，25 mg/kg；sc；两次给药，间隔 72 小时）在 20 mg/kg Chlordiazepoxide 诱导的习惯性遗忘症雄性大鼠中表现出阳性和记忆增强特性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult albino male rats (270-330 g) induced by Chlordiazepoxide[2]
Dosage: 5 mg/kg, 25 mg/kg
Administration: SC; 0.5 ml/kg; twice dose with 72 h interval; 1 h before 20 mg/kg Chlordiazepoxide
Result: Showed the positive effects on several learning and memory tasks in rats.
Did not influence locomotor and rearing activity of animals during the acquisition session.
分子量

415.52

Formula

C22H26FN3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sabeluzole 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sabeluzole104383-17-7R 58735R58735R-58735Tau ProteinInhibitorinhibitorinhibit

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