2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. SB-332235

SB-332235 是一种高效、口服活性、选择性的非肽 CXCR2 拮抗剂，IC50 为 7.7 nM。SB-332235 对 CXCR2 的选择性比 CXCR1 高 285 倍。SB-332235 对家兔急性和慢性关节炎模型的抑制作用。SB-332235 抑制 AML 细胞活性。

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SB-332235 Chemical Structure

SB-332235 Chemical Structure

CAS No. : 276702-15-9

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规格 价格 是否有货
10 mg ￥5418
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SB-332235 相关抗体

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB-332235 is a potent, orally active nonpeptide CXCR2 antagonist, with an IC50 of 7.7 nM. SB-332235 displays 285-fold selectivity for CXCR2 over CXCR1. SB-332235 inhibits acute and chronic models of arthritis in the rabbit. SB-332235 inhibits viability of AML cells[1][2].

体外研究
(In Vitro)

SB-332235 (1-100 μM; 48 hours) inhibits viability of AML cell lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SB-332235 相关抗体:

Cell Viability Assay[2]

Cell Line: AML cell
Concentration: 1, 10, 100 μM
Incubation Time: 48 hours
Result: Led to a dose-dependent decrease in proliferation in all cell lines.
体内研究
(In Vivo)

SB-332235 (25 mg/kg, p.o., b.i.d.) exhibits significantly reduced numbers of total leukocytes in synovial fluids from IL-8-injected knees[1].
SB-332235 (10-25 mg/kg; p.o.; twice a day for 14 days) inhibits chronic Ag-induced arthritis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female New Zealand White rabbits (chronic OVA-induced model of arthritis)[1]
Dosage: 10, 25 mg/kg
Administration: P.o.; twice a day for 14 days
Result: Day-15 synovial fluid leukocyte numbers in OVA-injected knees were significantly reduced in rabbits. The decrease in neutrophils, monocytes, and lymphocytes resulting from treatment with 25 mg/kg of the antagonist was accompanied by a significant reduction in synovial fluid PGE2, LTB4, LTC4, and IL-8 levels.
分子量

410.66

Formula

C13H10Cl3N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB-332235 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-332235276702-15-9SB332235SB 332235CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsselectiveacutechronicarthritisAMLcellsleukocytesInhibitorinhibitorinhibit

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目录号：
HY-16981
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