2. TGF-beta/Smad
  3. TGF-β Receptor
  4. SB-431542

SB-431542 (GMP) 是 GMP 级别的 SB-431542 (HY-10431)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。SB-431542 是 SMAD 信号传导中的 TGF-β 受体激酶抑制剂。

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SB-431542

SB-431542 Chemical Structure

CAS No. : 301836-41-9

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规格 价格 是否有货 数量
10 mg ￥12000
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SB-431542 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling[1][2][3].

IC50 & Target[1]

ALK4

1 μM (IC50)

ALK5

0.75 μM (IC50)

ALK7

2 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T IC50
0.066 μM
Compound: SB-431542, SB
Inhibition of TGBR2 signaling in human HEK293T cells assessed as inhibition of SMAD activation after 2 to 22 hrs by dual Luciferase Assay
Inhibition of TGBR2 signaling in human HEK293T cells assessed as inhibition of SMAD activation after 2 to 22 hrs by dual Luciferase Assay
[PMID: 23130626]
HaCaT EC50
172 nM
Compound: 1a, SB-431542
Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISA
Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISA
[PMID: 20919678]
HepG2 IC50
250 nM
Compound: SB-431542
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay
[PMID: 19914068]
NCI-H1299 IC50
0.5 μM
Compound: 3, SB-431542
Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay
Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay
[PMID: 24417479]
Sf9 IC50
1.542 μM
Compound: 1
Inhibition of human recombinant ALK5 phosphorylation expressed in Sf9 cells
Inhibition of human recombinant ALK5 phosphorylation expressed in Sf9 cells
[PMID: 17552507]
Sf9 IC50
67.1 nM
Compound: SB-431542
Inhibition of recombinant human N-terminal GST-tagged TGFbeta1 receptor (80 to end residues) expressed in baculovirus infected Sf9 insect cells using casein as substrate measured after 2 hrs by ADP-Glo assay
Inhibition of recombinant human N-terminal GST-tagged TGFbeta1 receptor (80 to end residues) expressed in baculovirus infected Sf9 insect cells using casein as substrate measured after 2 hrs by ADP-Glo assay
[PMID: 31408333]
体外研究
(In Vitro)

SB-431542 (GMP) (10 μM; 10 days) induces human pluripotent stem cells (hPSCs) to post-mitotic cortical neurons differentiation[1].
SB-431542 (GMP) (10 μM) facilitates directed differentiation into midbrain dopamine neurons (mDA)[2].
SB-431542 (GMP) (3.8 μM) promotes differentiation of hPSCs to multipotent hematopoietic progenitors that arise from SOX17+ hemogenic endothelium in vitro[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SB-431542 相关抗体:

RT-PCR[1]

Cell Line: Human pluripotent stem cells (hPSCs)
Concentration: 10 μM
Incubation Time: 10 days
Result: Showed downregulation of the pluripotency marker OCT4 and induction of neural and neuronal markers PAX6, FOXG1 and DCX, as well as markers of early born cortical neurons, including TBR1 (preplate, subplate and layer VI) and REELIN, in LSB+X/P/S/D conditions.
分子量

384.39

Formula

C22H16N4O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB-431542 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-431542 (GMP)301836-41-9TGF-β ReceptorTransforming growth factor beta receptorsmidbrain dopamine (mDA)neuronSMADhuman pluripotent stem cells (hPSCs)Inhibitorinhibitorinhibit

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产品名称：
SB-431542
目录号：
HY-10431G
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