phospho-Akt

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By Targets:	Apoptosis (1) HSP (2) Monoamine Oxidase (2) P2Y Receptor (1) PI3K (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1)

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Targets Recommended: Akt

Cat. No.	Product Name	Target	Research Area	Chemical Structure

(S)-PI3K-IN-2	PI3K	Cancer
(S)-PI3K-IN-2 是 PI3K-IN-2 (HY-101517) 的对映体，一种 ΡΙ3Κβ/δ 抑制剂，IC₅₀ 值分别为 0.198 和 0.282 μM。(S)-PI3K-IN-2 可以抑制 MDA-MB-468 细胞中的磷酸化 AKT (ser473) (IC₅₀=27 nM)。

MAO A/HSP90-IN-1	Monoamine Oxidase HSP	Cancer
MAO A/HSP90-IN-1 (4-b) 是一种 MAO A/HSP90 双抑制剂，在恶性胶质瘤 GL26 细胞中的 IC₅₀ 值为1.77 μM，对 HSP90α 的IC₅₀ 值为0.019 μM。MAO A/HSP90-IN-1 (4-b) 通过抑制 MAO A 的活性，HSP90 的结合以及 HER2 和 phospho-Akt 的表达来抑制恶性胶质瘤 (GMB)，它们还能减少抑制 T 细胞活化的 PD-L1 表达，具有抑制肿瘤免疫逃逸的潜力。可用于脑肿瘤相关疾病的研究。

MAO A/HSP90-IN-2	Monoamine Oxidase HSP	Cancer
MAO A/HSP90-IN-2 (compound 4-C) 是 HSP90 和 MAO A 双抑制剂，其 IC₅₀ 值分别为 0.016 和 4.58 μM。MAO A/HSP90-IN-2 上调 HSP70 表达，下调 HER2 和磷酸化 AKT 表达，以及 GL26 细胞中 IFN-γ 诱导的 PD-L1 的上升。MAO A/HSP90-IN-2 可以抑制 Temozolomide (HY-17364) 敏感和耐药的 GBM 细胞胶质瘤、结肠癌、白血病和非小细胞肺癌等癌症的生长，具有抑制肿瘤免疫逃逸的潜力。

Diquafosol INS365 free base	Apoptosis P2Y Receptor Reactive Oxygen Species (ROS)	Inflammation/Immunology
Diquafosol (INS365 free base) 是一种有效的 P2Y2 激动剂。Diquafosol 可抑制细胞凋亡 (apoptosis) 并减少 ROS 生成。Diquafosol 具有用于研究干眼症的潜力。

Cat. No.	Compare	Product Name	Application	Reactivity

	Phospho-AKT (Thr308) Antibody Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	ICC/IF, WB, IHC-F, IHC-P, ELISA	Human, Mouse, Rat
	Phospho-AKT (Thr308) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-AKT (Thr308).

	Phospho-AKT(Thr308) Antibody (YA5837) (YA5837)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-AKT(Thr308) Antibody (YA5837) (YA5837) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AKT(Thr308).

	Phospho-AKT1 (Ser473) Antibody (YA228) 2 篇文献验证 Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB	Human, Mouse, Rat
	Phospho-AKT1 (Ser473) Antibody (YA228) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AKT1 (Ser473).

	Phospho-AKT1(Ser473) Antibody (YA227) 1 篇文献验证 Akt 1 antibody; Akt antibody; Akt1 antibody; Akt1_HUMAN antibody; MGC99656 antibody; PKB antibody; PKB-ALPHA antibody; PRKBA antibody; Protein Kinase B Alpha antibody; Protein kinase B antibody; Proto-oncogene c-Akt antibody; RAC Alpha antibody; RAC antibody; RAC-alpha serine/threonine-protein kinase antibody; RAC-PK-alpha antibody;	WB, ICC/IF, IHC-P	Human, Mouse, Rat, Dog
	Phospho-AKT1(Ser473) Antibody (YA227) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AKT1(Ser473).

	Phospho-AKT(S473) Antibody (YA5759) Akt1	WB, IHC-P, ICC/IF	Human
	Phospho-AKT(S473) Antibody (YA5759) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Phospho-AKT(S473).

	Phospho-AKT(Ser473) Antibody (YA6142) (YA6142)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-AKT(Ser473) Antibody (YA6142) (YA6142) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AKT(Ser473).

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