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  3. Secnidazole hemihydrate

Secnidazole hemihydrate  (Synonyms: 塞克硝唑半水合物; RP-14539 hemihydrate; PM-185184 hemihydrate)

目录号: HY-B1118A
产品使用指南

Secnidazole (RP-14539) hemihydrate 是一种唑类抗生素和黏质沙雷菌毒力的咪唑缓释剂,具有口服活性。Secnidazole hemihydrate 作为一种类似于酰基高丝氨酸内酯,能有效抑制 QS 导致铜绿假单胞菌的发病衰减。Secnidazole hemihydrate 在体外对多种厌氧革兰氏阴性和革兰氏阳性细菌均有抗菌活性。Secnidazole hemihydrate 可用于各种疾病的研究,如阿米巴病和贾第虫病,以及细菌性阴道炎。

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Secnidazole hemihydrate Chemical Structure

Secnidazole hemihydrate Chemical Structure

CAS No. : 227622-73-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Secnidazole (RP-14539) hemihydrate is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole hemihydrate, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole hemihydrate has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole hemihydrate can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].

IC50 & Target

Amebae

 

体外研究
(In Vitro)

Secnidazole (RP-14539) hemihydrate (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC50 values of 3873 μM and 3722 μM, respectively[2].
Secnidazole hemihydrate (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition[2].
Secnidazole hemihydrate (0-5000 μM; 5 or 10 min) has an apparent IC50 value of 503 μM for direct inhibition of human ALDH2[2].
Secnidazole hemihydrate (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6[2].
Secnidazole hemihydrate (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibits S.marcescens growth with a MIC50 value of 10 mg/mL[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: S.marcescens
Concentration: 10 μL (the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL)
Incubation Time: 20 h
Result: Had no inhibitory effect on S.marcescens growth at 2 mg/mL (equivalent to 1/5 MIC).
体内研究
(In Vivo)

Secnidazole (RP-14539) hemihydrate (100 μL; ip.; for 5 days) has protective activity against S.marcescens pathogenesis and can diminish its pathogenesis in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female healthy albino mice[3]
Dosage: 100 μL
Administration: 100 μL; ip.; for 5 days
Result: Significantly diminished the bacteria s capacity to kill mice.
Clinical Trial
分子量

194.19

Formula

C7H13N3O4

CAS 号
中文名称

塞克硝唑半水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Secnidazole hemihydrate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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