2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB
  3. SHMT Apoptosis Reactive Oxygen Species (ROS)
  4. SHMT2-IN-1

SHMT2-IN-1 是一种强效的丝氨酸羟甲基转移酶 2 (SHMT2) 抑制剂，其 IC50 值为 1.21 μM，KD 值为 10.6 μM。SHMT2-IN-1 与 SHMT2 的叶酸结合位点结合。SHMT2-IN-1 还能抑制 SHMT1，其 IC50 值为 1.83 μM。MT-44 能够抑制癌细胞的增殖、迁移和侵袭。MT-44 可以诱导细胞凋亡 (apoptosis) 和活性氧 (ROS) 的产生，并导致 G2/M 期阻滞。SHMT2-IN-1 可用于癌症研究，如食管癌。

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SHMT2-IN-1

SHMT2-IN-1 Chemical Structure

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SHMT2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 SHMT 亚型特异性产品:

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SHMT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SHMT2-IN-1 is a potent serine hydroxymethyltransferase 2 (SHMT2) inhibitor with an IC50 of 1.21 μM and a KD of 10.6 μM. SHMT2-IN-1 binds to the folate binding site of SHMT2. SHMT2-IN-1 also inhibits SHMT1 with an IC50 of 1.83 μM. SHMT2-IN-1 can inhibit cancer cells proliferation, migration and invasion. SHMT2-IN-1 can induce cells apoptosis and ROS production and cause G2/M phase arrest. SHMT2-IN-1 can be used for the research of cancer, such as esophageal cancer[1].

IC50 & Target[1]

SHMT2

1.21 μM (IC50)

Human SHMT1

1.83 μM (IC50)

体外研究
(In Vitro)

SHMT2-IN-1 (0.1-10 μM, 24 h) 对食管癌细胞 KYSE-450 和 KYSE-70 具有强效抗增殖活性，IC50 分别为 1.62 μM 和 1.18 μM[1]。
SHMT2-IN-1 (2.5-10 μM, 24 h) 剂量依赖性抑制 KYSE-450 和 KYSE-70 细胞迁移和侵袭[1]。
SHMT2-IN-1 (2.5-7.5 μM, 24-72 h) 诱导 KYSE-450 和 KYSE-70 细胞凋亡，产生活性氧并引起 G2/M 期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SHMT2-IN-1 相关抗体:

Apoptosis Analysis[1]

Cell Line: KYSE-450 and KYSE-70 cells
Concentration: 2.5, 5 and 7.5 μM
Incubation Time: 72 h
Result: Increased apoptotic cells.
Upregulated Bax expression and downregulated Bcl-2, Pro-Caspase 3 and Pro-Caspase 9 expression.
分子量

558.03

Formula

C26H16ClN7O2S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SHMT2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHMT2-IN-1SHMTApoptosisReactive Oxygen Species (ROS)Serine hydroxymethyltransferaseserine hydroxymethyltransferaseSHMT2SHMT1apoptosisROSesophageal cancerKYSE-450KYSE-70Inhibitorinhibitorinhibit

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