1. Anti-infection
  2. Parasite
  3. SJ000025081

SJ000025081 

目录号: HY-136448
产品使用指南

SJ000025081 是一种二氢吡啶,可作为一种抗疟剂 (antimalarial agent)。SJ000025081 在小鼠疟疾模型中明显抑制 P. yoelii 感染的寄生虫血症。

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SJ000025081 Chemical Structure

SJ000025081 Chemical Structure

CAS No. : 421571-66-6

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Description

SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii[1].

In Vivo

SJ000025081 (intraperitoneal injection; 25 mg/kg; single dose; suspension in 1% methylcellulose) exhibits a good PK profile, the Cmax, Cmax/Dose, Tmax and AUC values are 0.224 µg/ml, 0.0113 µg/ml per mg/ml, 1.0 h and 0.224 µg.h/ml, respectively[1].
SJ000025081 (intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days) exhibits an antimalarial activity in a dose-dependent manner and displays efficacy in a murine malaria model infected with P. yoelii. SJ000025081 can result in a 90% suppression of the parasitemia[1].

Animal Model: 6 weeks old CD-1 mice[1]
Dosage: 5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration: Intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days
Result: Was active in a malaria murine model infected with P. yoelii.
Molecular Weight

479.54

Formula

C₂₈H₃₀FNO₅

CAS No.

421571-66-6

SMILES

O=C(C1=C(C)NC2=C(C(CC(C3=CC=C(OC)C(OC)=C3)C2)=O)C1C4=CC=CC=C4F)OCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SJ000025081SJ 000025081SJ-000025081ParasiteantimalarialparasitemiamalariaP. yoeliidihydropyridinePlasmodium falciparumInhibitorinhibitorinhibit

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产品名称:
SJ000025081
目录号:
HY-136448
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