2. Cell Cycle/DNA Damage Epigenetics Autophagy
  3. Sirtuin Autophagy
  4. SKLB-11A

SKLB-11A 是一种选择性、口服有效的变构 SIRT3 (sirtuin 3) 激动剂，Kd 值为 4.7 μM。SKLB-11A 对 SIRT 家族的其他成员具有高度选择性。SKLB-11A 可激活自噬 (autophagy) 相关的信号通路，预防线粒体功能障碍，并在 Doxorubicin (HY-15142A) 诱发的心脏毒性和心肌缺血/再灌注模型中改善心脏功能。

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SKLB-11A

SKLB-11A Chemical Structure

CAS No. : 433953-86-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1096
In-stock
5 mg ￥997
In-stock
10 mg ￥1400
In-stock
25 mg ￥2397
In-stock
50 mg ￥4100
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

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SKLB-11A 相关抗体

Top Publications Citing Use of Products

查看 Sirtuin 亚型特异性产品:

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SKLB-11A is a selective, orally active and allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 μM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin (HY-15142A)-induced cardiotoxicity and myocardial ischemia/reperfusion models[1].

IC50 & Target

SIRT3

4.7 μM (Kd)

体外研究
(In Vitro)

SKLB-11A 可增强 SIRT3 去乙酰化活性，EC50 为 21.95 μM[1]。
SKLB-11A (0.625-5 μM；24 小时) 不会改变 SIRT3 蛋白水平，但可显著增强 H9c2 细胞中的 SIRT3 活性[1]。
SKLB-11A 可与 SIRT3 高亲和力结合，并增强其与 p53-Ac 底物的相互作用[1]。
SKLB-11A (5-20 μM；24 小时) 可改善 Doxorubicin 诱导的线粒体损伤，并促进 H9c2 细胞中 SIRT3 介导的自噬[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SKLB-11A 相关抗体:

Western Blot Analysis[1]

Cell Line: H9c2 cells
Concentration: 0.625 μM, 1.25 μM, 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Induced deacetylation at K122 and K68, resulting in enhanced MnSOD enzymatic activity.
Activated endogenous SIRT3 deacetylation in H9c2 cells.

Western Blot Analysis[1]

Cell Line: H9c2 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 24 h
Result: Increased LC3-II expression and reduced p62 levels, indicating enhanced autophagic flux.
Increased the expression of PINK1 and Parkin, and promoted colocalization of mitochondria with Parkin and LC3-II.
体内研究
(In Vivo)

SKLB-11A (10-20 mg/kg；每日一次，灌胃；连续 7 天) 预处理可抑制小鼠 Doxorubicin 诱发的心脏功能障碍[1]。
SKLB-11A (20 mg/kg；每日一次，灌胃；连续 7 天) 治疗可减轻小鼠缺血/再灌注 (I/R) 诱发的心肌损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (8 weeks, ~23 g)[1]
Dosage: 10 and 20 mg/kg/day
Administration: Oral gavage; daily; for 7 days; then injected Doxorubicin intraperitoneally for 2 weeks
Result: Significantly restored left ventricular ejection fraction (EF) and fractional shortening (FS) in a dose-dependent manner.
Partially reversed Doxorubicin-induced weight loss and reduced serum markers of myocardial injury, including LDH, CK-MB, and BNP.
Preserved myocardial structure and alleviated pathological damage.
Demonstrated no apparent toxicity at effective doses, as evidenced by preserved organ histology in the heart, liver, spleen, lungs, and kidneys.
Animal Model: Male C57BL/6J mice (8-12 weeks old) was induced myocardial ischemia-reperfusion (I/R) injury[1].
Dosage: 20 mg/kg
Administration: Oral gavage; daily; for 7 days
Result: Restored cardiac function impaired by I/R injury.
Partially reversed I/R-induced elevations in serum myocardial injury markers, including LDH, CK-MB, and BNP.
Markedly reduced I/R-induced cardiac fibrosis.
分子量

350.35

Formula

C19H15FN4O2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 7.78 mg/mL (22.21 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8543 mL 14.2714 mL 28.5429 mL
5 mM 0.5709 mL 2.8543 mL 5.7086 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SKLB-11A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8543 mL 14.2714 mL 28.5429 mL 71.3572 mL
5 mM 0.5709 mL 2.8543 mL 5.7086 mL 14.2714 mL
10 mM 0.2854 mL 1.4271 mL 2.8543 mL 7.1357 mL
15 mM 0.1903 mL 0.9514 mL 1.9029 mL 4.7571 mL
20 mM 0.1427 mL 0.7136 mL 1.4271 mL 3.5679 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKLB-11A433953-86-7SirtuinAutophagySIRT3autophagycardiotoxicityischemia/reperfusionInhibitorinhibitorinhibit

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