2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. SRI 31215

SRI 31215 是 Matriptase/Hepsin/HGFA 三重抑制剂，模拟 HAI-1/2 (HGF活化的内源性抑制剂) 的活性。 SRI 31215 对 matriptase、hepsin 和 HGFA 具有有效的抑制活性，IC50 值分别为 0.69 μM、0.65 μM 和 0.30 μM。SRI 31215 可用于癌症研究。

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SRI 31215

SRI 31215 Chemical Structure

CAS No. : 1832686-43-7

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SRI 31215 的其他形式现货产品:

Customer Review

Other Forms of SRI 31215:

SRI 31215 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SRI 31215 is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer[1].

体外研究
(In Vitro)

SRI 31215 对 matriptase、hepsin 和 HGFA 具有有效活性，IC50 值分别为 0.69 μM、0.65 μM 和 0.30 μM[1]。
SRI 31215 (10 μM) 抑制 pro-HGF 的蛋白水解激活[1]。
SRI 31215 (10 μM，30 min) 抑制成纤维细胞诱导的肿瘤细胞中的 HGF/MET 信号传导[1]。
SRI 31215 (10 μM，24 小时) 抑制肿瘤细胞中成纤维细胞诱导的上皮间质转化 (EMT) 和迁移[1]。
SRI 31215 (10 μM) 克服结肠癌细胞中自分泌 HGF/MET 信号介导的对 EGFR 抑制剂的耐药性[1]。
SRI31215 (10 μM，72 小时) 避免成纤维细胞介导的对 EGFRi 诱导的细胞凋亡的抗性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SRI 31215 相关抗体:

Western Blot Analysis[1]

Cell Line: DU145 cells
Concentration: 10 μM
Incubation Time: 30 min
Result: Prevented fibroblast-induced MET activation and signaling in tumor cells, but did not prevent MET activation induced by active HGF.

Cell Migration Assay [1]

Cell Line: DU145 cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Did not interfere with HGF-induced migration, but inhibited fibroblast-induced migration of DU145 cells.
分子量

419.56

Formula

C25H33N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SRI 31215 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRI 312151832686-43-7SRI31215SRI-31215c-Met/HGFRMatriptaseHepsinhepatocyte growth factor activatorHGFAHAI-1/2HGFcancerInhibitorinhibitorinhibit

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