2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SRTCX1003

SRTCX1003 是一种具有口服活性的 SIRT1 激活剂。SRTCX1003 抑制炎症反应。

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SRTCX1003 Chemical Structure

SRTCX1003 Chemical Structure

CAS No. : 1203480-86-7

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SRTCX1003 相关抗体

Top Publications Citing Use of Products

查看 Sirtuin 亚型特异性产品:

查看所有亚型
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SRTCX1003 is an orally active SIRT1 activator. SRTCX1003 suppresses inflammatory responses[1].

IC50 & Target

SIRT1[1]
体外研究
(In Vitro)

SRTCX1003 (0-10 μM; 24 h) 剂量依赖性降低 U2OS 细胞中乙酰化 p65 蛋白[1]。
SRTCX1003 (5 μM; 6 h) 减弱 HEK 293T/17 细胞中 TNFα 诱导的 p65 乙酰化[1]。
SRTCX1003 (0-100 μM; 2 h) 剂量依赖性减少 RAW 细胞中 LPS (HY-D1056) 诱导的 TNFα 分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SRTCX1003 相关抗体:

Western Blot AnalysisHEK 293T/17

Cell Line: HEK 293T/17
Concentration: 5 μM
Incubation Time: 6 h followed by 20 minutes TNFα stimulation
Result: Significantly reduced TNFα-stimulated p65 acetylation.
体内研究
(In Vivo)

SRTCX1003 (3-100 mg/kg; oral; once) 在小鼠炎症模型中降低 LPS (HY-D1056) 刺激的 TNFα 和 IL-12p40 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice, LPS-induced inflammation mouse model[1]
Dosage: 3, 10, 30 and 100 mg/kg
Administration: Oral, 60 minutes prior to LPS administration
Result: Dose-dependently reduced LPS-stimulated TNFα and IL-12p40 production.
分子量

449.53

Formula

C23H23N5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SRTCX1003 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRTCX10031203480-86-7SRTCX 1003SRTCX-1003Sirtuinorally activep65TNFαHEK 293T/17RAW cellIL-12p40Inhibitorinhibitorinhibit

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产品名称：
SRTCX1003
目录号：
HY-124240
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