Tandospirone hydrochloride  (Synonyms: 盐酸坦度螺酮; SM-3997 hydrochloride)

Tandospirone (SM-3997) hydrochloride is a potent and selective 5-HT_1A receptor partial agonist, with a K_i of 27 nM. Tandospirone hydrochloride has anxiolytic and antidepressant activities. Tandospirone hydrochloride can be used for the research of the central nervous system disorders and the underlying mechanisms^[1][2][3].

Tandospirone (SM-3997) hydrochloride is approximately two to three orders of magnitude less potent at 5-HT₂, 5-HT_1C, α1-adrenergic, α2-adrenergic and dopamine D1 and D2 receptors (K_i values ranging from 1300 to 41000 nM) than 5-HT_1A^[1].
Tandospirone hydrochloride is essentially inactive at 5-HT_1B receptors; 5-HT uptake sites; beta-adrenergic, muscarinic cholinergic, and benzodiazepine receptors^[1].
Tandospirone hydrochloride activates postsynaptic 5-HT_1A receptor coupled with G-protein (G_i/o), resulting in inhibition of protein kinase A (PKA)-mediated protein phosphorylation and neuronal activity^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tandospirone (SM-3997) hydrochloride (10-80 mg/kg; i.p.) inhibits freezing behavior in the conditioned fear stress-induced freezing behavior rat model^[3].
Tandospirone hydrochloride exhibits the anxiolytic effect dependent on the plasma concentration of at 0.5 hours but not 4 hours^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

419.95

C₂₁H₃₀ClN₅O₂

99095-10-0

盐酸坦度螺酮；盐酸枸橼酸坦度螺酮

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28(2):99-109.  [Content Brief]

  [2]. Xuefei Huang, et al. Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. Oncotarget. 2017 Nov 24; 8(60): 102705–102720.  [Content Brief]

  [3]. Kyoko Nishitsuji, et al. The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress. Eur Neuropsychopharmacol. 2006 Jul;16(5):376-82.  [Content Brief]