1. Apoptosis
  2. Apoptosis
  3. Tasisulam

Tasisulam (Synonyms: LY 573636)

目录号: HY-14804
产品使用指南

Tasisulam 是一种小分子抗肿瘤药物,可抑制有丝分裂进程并诱导血管正常化。Tasisulam 通过内在途径诱导细胞凋亡

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Tasisulam Chemical Structure

Tasisulam Chemical Structure

CAS No. : 519055-62-0

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Description

Tasisulam is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam induces apoptosis via the intrinsic pathway[1].

In Vitro

Tasisulam (200 μM-200 nM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1].
Tasisulam (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1].
Tasisulam (200 μM-200 nM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1].

Cell Proliferation Assay[1]

Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models
Concentration: 200 μM-200 nM
Incubation Time: 48 hours
Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s are 10 μM and 25 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: Calu-6 and A-375 cell lines
Concentration: 25, 50 μM
Incubation Time: 72 hours
Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation.

Apoptosis Analysis[1]

Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models
Concentration: 200 μM-200 nM
Incubation Time: 48 hours
Result: Induced apoptosis in a broad range of in vitro cancer cell models.
Molecular Weight

415.11

Formula

C₁₁H₆BrCl₂NO₃S₂

CAS No.

519055-62-0

SMILES

O=C(NS(=O)(C1=CC=C(Br)S1)=O)C2=CC=C(Cl)C=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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× = ×
C1   V1   C2   V2

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产品名称:
Tasisulam
目录号:
HY-14804
需求量:

Tasisulam

Cat. No.: HY-14804